Countless patients suffer from neurological diseases every year. These neurodegenerative diseases or rare diseases often lead to motor dysfunction, neurological disorders, and other symptoms, which seriously affect the lives of patients. From common diseases such as Alzheimer's disease to more rare neurological diseases, tremendous efforts have been made to better understand their mechanisms, characteristics and possible intervention strategies. Some focus on the use of laboratory animals to mimic genetic defects in humans, while others identify biomarkers to track disease progression. As a leader in the field of biological sciences, Creative Biolabs is committed to providing our clients around the world with the most convenient and accurate biomarker analysis. Years of experience have rewarded us with knowledge and technology proven to be essential for precise biomarker assay for the following diseases:
According to statistics, more than 50 million individuals in the world currently suffer from neurodegenerative diseases, and Alzheimer's disease (AD) accounts for about 62% of these cases. AD causes visuospatial, memory and executive impairment, and eventually generalized dementia. With our outstanding staff, Creative Biolabs can complete accurately and early Alzheimer's disease marking and identification ex vivo. Our commonly used biomarkers include Aβ 38/40/42 and tau/ptau.
Fig 1. The core cerebrospinal fluid Alzheimer's disease biomarkers and the novel synaptic biomarker candidate neurogranin. (Blennow, 2018)
Amyotrophic lateral sclerosis is a rare but severe motor neuron disease caused by the damage of the upper and lower motor neurons, which gradually causes weakness and atrophy of the limbs, trunk, chest and abdominal muscles. Creative Biolabs can perform ex vivo assay of ALS classic biomarkers including SOD1, FUS, TDP-43, and C9orf72 for accurate ALS identification.
Multiple sclerosis is a central nervous system white matter inflammatory demyelinating disease caused by autoimmune disorders, and often concentrated in the white matter, optic nerve, spinal cord, brain stem, cerebellum, etc. The most important features of MS are the multifocality in the nervous system, the spatial multiplicity of symptoms and the remission and recurrence of the disease course. Creative Biolabs is well aware of the importance of accurate and rapid biomarker identification in the study of MS timeliness and recurrence, so we provide comprehensive and convenient biomarker assay services for your project.
Fig 2. Lipofuscin accumulation is commonly used as a marker of cellular senescence in multiple sclerosis lesions. (Kritsilis, 2018)
At Creative Biolabs, we can achieve professional and first-class biomarker analysis by using validated approaches and cutting-edge technologies. In addition to the above services, we can also design, improve or develop new analysis solutions according to your research direction. If we can improve your project in any way or you have any further demands, please don't hesitate to contact us.
- Kritsilis, M.; et al. Ageing, cellular senescence and neurodegenerative disease. International Journal of Molecular Sciences. 2018, 19: 2937.
- Blennow K.; Zetterberg H. Biomarkers for Alzheimer's disease: current status and prospects for the future. J Intern Med. 2018, 284(6): 643-663.