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- A Brainwide Atlas of Synapses Across the Mouse Life Span
- A Circadian Rhythm-Gated Subcortical Pathway for Nighttime-Light-Induced Depressive-Like Behaviors in Mice
- A Functional Map for Diverse Forelimb Actions within Brainstem Circuitry
- A Recurrent GOF Mutation in CLCN6 Causes Early-Onset Neurodegeneration
- An Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques
- Antidepressant Actions of Ketamine Engage Cell-Specific Translation via eIF4E
- Applications of Machine Learning to Diagnosis and Treatment of Neurodegenerative Diseases
- Association of Klotho-VS Heterozygosity With Risk of AD in Individuals with APOE4
- Association of Symptoms of Depression With Cardiovascular Disease
- Association of Youth Depression With Somatic Diseases and Premature Death
- Astrocytes Phagocytose Adult Hippocampal Synapses for Circuit Homeostasis
- Base Editing Strategy Allows Insertion of the A673T Mutation in APP Gene to Prevent the Development of Alzheimer's Disease
- Bidirectional Perisomatic Inhibitory Plasticity of a Fos Neuronal Network
- Cell Type-Specific Lipid Storage Changes in Parkinson's Disease Patient Brains are Recapitulated by Experimental Glycolipid Disturbance
- Chi3l1/YKL-40 Is Controlled by the Astrocyte Circadian Clock and Regulates Neuroinflammation and Alzheimer's Disease Pathogenesis
- CLR01 Protects Dopaminergic Neurons In Vitro and in Mouse Models of Parkinson's Disease
- Cranial Suture Regeneration and Craniosynostosis
- Cryo-EM Structure of Islet Amyloid Polypeptide Fibrils Reveals Similarities with Amyloid-β Fibrils
- Depression in Individuals who Subsequently Develop Inflammatory Bowel Disease: A Population-Based Nested Case-Control Study
- Diabetes Medications and Risk of Parkinson's Disease: A Cohort Study of Patients with Diabetes
- Differential Attentional Control Mechanisms by Two Distinct Noradrenergic Coeruleo-Frontal Cortical Pathways
- Effects of Acute Sleep Loss on Diurnal Plasma Dynamics of CNS Health Biomarkers in Young Men
- Estrogen Receptor-α Expressing Neurons in the Ventrolateral VMH Regulate Glucose Balance
- Evidence-Based Prevention of Alzheimer's Disease: Systematic Review and Meta-Analysis of 243 Observational Prospective Studies and 153 Randomised Controlled Trials
- Flexible and Stretchable Opto-Electric Neural Interface for Low-Noise Electrocorticogram Recordings and Neuromodulation In Vivo
- Flexible Fiber Probe for Efficient Neural Stimulation and Detection
- Forelimb Movements Evoked by Optogenetic Stimulation of the Macaque Motor Cortex
- G3BPs Tether the TSC Complex to Lysosomes and Suppress mTORC1 Signaling
- GABAergic Signaling to Astrocytes in the Prefrontal Cortex Sustains Goal-Directed Behaviors
- HSP40 Proteins Use Class-Specific Regulation to Drive HSP70 Functional Diversity
- IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition
- Increased Dopamine Transmission and Adult Neurogenesis in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice
- Landscapes of Bacterial and Metabolic Signatures and Their Interaction in Major Depressive Disorders
- Large-Scale Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation
- M2 Cortex-Dorsolateral Striatum Stimulation Reverses Motor Symptoms and Synaptic Deficits in Huntington's Disease
- Manipulating Synthetic Optogenetic Odors Reveals the Coding Logic of Olfactory Perception
- mGlu2- and mGlu3- Allosteric Modulators Enhance Thalamocortical Transmission
- MIND and Mediterranean Diets Associated with Later Onset of PD
- Mitochondrial Damage-Associated Inflammation Highlights Biomarkers in PRKN/PINK1 Parkinsonism
- Molecular Dissection of Amyloid Disaggregation by Human HSP70
- N-3 Polyunsaturated Fatty Acids Promote Astrocyte Differentiation and Neurotrophin Production Independent of cAMP in Patient-Derived Neural Stem Cells
- Nanozyme Scavenging ROS for Prevention of Pathologic α-Synuclein Transmission in Parkinson's Disease
- Neuroblast Senescence in the Aged Brain Augments Natural Killer Cell Cytotoxicity Leading to Impaired Neurogenesis and Cognition
- NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans
- Noncanonical Transnitrosylation Network Contributes to Synapse Loss in Alzheimer's Disease
- Patterns of De Novo Tandem Repeat Mutations and Their Role in Autism
- Postnatal Connectomic Development of Inhibition in Mouse Barrel Cortex
- Regulation of Sleep Homeostasis Mediator Adenosine by Basal Forebrain Glutamatergic Neurons
- Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Ageing
- Severe Reactive Astrocytes Precipitate Pathological Hallmarks of Alzheimer's Disease via H2O2- Production
- Single-Nucleus Transcriptome Analysis Reveals Dysregulation of Angiogenic Endothelial Cells and Neuroprotective Glia in Alzheimer's Disease
- Small Molecule Cognitive Enhancer Reverses Age-Related Memory Decline in Mice
- STAT3 in the Dorsal Raphe Gates Behavioural Reactivity and Regulates Gene Networks Associated with Psychopathology
- Tau PTM Profiles Identify Patient Heterogeneity and Stages of AD
- The Innate Immunity Protein IFITM3 Modulates γ-Secretase in Alzheimer's Disease
- αS Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons
- β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
- A Novel and Accurate Full-Length HTT Mouse Model for Huntington's Disease
- Assessment of Neurovascular Coupling and Cortical Spreading Depression in Mixed Mouse Models of Atherosclerosis and Alzheimer's Disease
- BET1 Variants Establish Impaired Vesicular Transport as a Cause for Muscular Dystrophy with Epilepsy
- Blood-Based Biomarkers for Alzheimer's Disease
- Caldendrin and Myosin V Regulate Synaptic Spine Apparatus Localization via ER Stabilization in Dendritic Spines
- Comparative Study of Brain fMRI of Olfactory Stimulation in NMOSD and MS
- Cysteine String Protein Controls Two Routes of Export for Misfolded Huntingtin
- DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors
- Enrichment of SARM1 Alleles Encoding Variants with Constitutively Hyperactive Nadase in Patients with ALS and Other Motor Nerve Disorders
- Genome-Wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis
- Human ALS/FTD Brain Organoid Slice Cultures Display Distinct Early Astrocyte and Targetable Neuronal Pathology
- Learning and Attention Increase Visual Response Selectivity through Distinct Mechanisms
- Loss of TREM2 Rescues Hyperactivation of Microglia, But Not Lysosomal Deficits and Neurotoxicity in Models of Progranulin Deficiency
- Macrophages Transfer Mitochondria to Sensory Neurons to Resolve Inflammatory Pain
- Make War Not Love: The Neural Substrate Underlying a State-Dependent Switch in Female Social Behavior
- Microglial PD-1 Stimulation by Astrocytic PD-L1 Suppresses Neuroinflammation and Alzheimer's Disease Pathology
- Mouse Visual Cortex Areas Represent Perceptual and Semantic Features of Learned Visual Categories
- Myelinating Schwann Cells and Netrin-1 Control Intra-Nervous Vascularization of the Developing Mouse Sciatic Nerve
- Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from AD
- Neurotoxin-Mediated Potent Activation of the Axon Degeneration Regulator SARM1
- Postnatal Expression of the Lysine Methyltransferase SETD1B is Essential for Learning and the Regulation of Neuron-Enriched Genes
- Synaptic Targets of Photoreceptors Specialized to Detect Color and Skylight Polarization in Drosophila
- Serotonergic Neurons Translate Taste Detection into Internal Nutrient Regulation
- Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of AD
- The Preference for Sugar Over Sweetener Depends on a Gut Sensor Cell
- The SARS-CoV-2 Main Protease Mpro Causes Microvascular Brain Pathology by Cleaving NEMO in Brain Endothelial Cells
- Trans ε-Viniferin Decreases Amyloid Deposits with Greater Efficiency Than Resveratrol in an Alzheimer's Mouse Model
- Transcriptomic Taxonomy and Neurogenic Trajectories of Adult Human, Macaque, and Pig Hippocampal and Entorhinal Cells
- Nature Aging: Glial Cells Identify and Clear Aβ through the VCAM1-ApoE Pathway and Alleviating Alzheimer's Disease Pathology
- Cell Stem Cell: Transplanting Neurons for Epilepsy Treatment Achieves a New Breakthrough
- Nature Communications: Scientists Identify Unique Circular RNAs in Parkinson's Disease
- Science: New Study Reveals the Mechanism of The Extensive Neuronal Loss in Alzheimer's Disease
- Nature Communications: Scientists Identified a Calcium Ion Channel Linked to Brain Inflammation
- Neuron: New Discovery Subverts Common Understanding of Parkinson's Disease Causation
- Science: Presynaptic Ube3a E3 Ligase Facilitates Synaptic Elimination by Suppressing BMP Signaling
- Nature: Newly Discovered Special Neurons - Glutamatergic Astrocytes
- Brain: Restoring KCC2 in Neurons Holds Promise for Improving Cognitive Performance of Alzheimer's Disease
Comparative Study of Brain fMRI of Olfactory Stimulation in Neuromyelitis Optica Spectrum Disease and Multiple Sclerosis
Objective: To observe the characteristics of brain fMRI during olfactory stimulation in patients
with neuromyelitis optica spectrum disease (NMOSD) and multiple sclerosis (MS), compare the
differences of brain functional activation areas between patients with NMOSD and MS, and explore the
characteristics of olfactory-related brain networks of NMOSD and MS.
Methods: Nineteen patients with NMOSD and 16 patients with MS who met the diagnostic criteria were
recruited, and 19 healthy controls matched by sex and age were recruited. The olfactory function of
all participants was assessed using the visual analog scale (VAS). Olfactory stimulation was
alternately performed using a volatile body (lavender and rose solution) and the difference in brain
activation was evaluated by task-taste fMRI scanning simultaneously.
Results: Activation intensity was weaker in the NMOSD group than in the healthy controls, including
the left rectus, right superior temporal gyrus, and left cuneus. The activation intensity was
stronger for the NMOSD than the controls in the left insula and left middle frontal gyrus (P
>
0.05). Activation intensity was weaker in the MS group than the healthy controls in the
bilateral hippocampus, right parahippocampal gyrus, right insula, left rectus gyrus, and right
precentral gyrus, and stronger in the left paracentral lobule among the MS than the controls
(P > 0.05). Compared with the MS group, activation intensity in the NMOSD group was weaker
in the
right superior temporal gyrus and left paracentral lobule, while it was stronger among the NMOSD
group in the bilateral insula, bilateral hippocampus, bilateral parahippocampal gyrus, left
inferior orbital gyrus, left superior temporal gyrus, left putamen, and left middle frontal
gyrus (P > 0.05).
Conclusion: Olfactory-related brain networks are altered in both patients, and there are differences
between their olfactory-related brain networks. It may provide a new reference index for the
clinical differentiation and disease evaluation of NMOSD and MS. Moreover, further studies are
needed.
Reference
Ting Ting, P., Wei Wei, H., Juan, T., Chang Yue, H., Chen, G., & Xiao Ming, W. Comparative Study of Brain fMRI of Olfactory Stimulation in Neuromyelitis Optica Spectrum Disease and Multiple Sclerosis. Frontiers in Neuroscience, 1844.
