Neurochemistry Assay Services

Our advanced neurochemistry assay delivers the sensitivity and multidimensionality you need for groundbreaking neuroscience. From basic research to preclinical trials, we provide customizable solutions that redefine precision. For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.

Our Technology Platform

• Integrated Electrophysiological and Pharmacological Analysis

Our advanced multi-electrode array (MEA) and patch clamp systems provide powerful tools for researchers investigating neuronal networks. These technologies support detailed network activity recording and mechanism verification in complex models like acute brain slices and iPSC-derived neurons, offering unparalleled accuracy in assessing compound modulation of synaptic transmission and plasticity.

• Ultra-Sensitive Neurochemistry Quantification

Leverage the power of our advanced UHPLC-MS/MS platform for ultra-sensitive, high-throughput neurochemical analysis. Quantify over 70 critical substances, including dopamine, 5-HT, and glutamate, with unparalleled accuracy down to sub-pg/mL levels. Ideal for complex matrices like cerebrospinal fluid and tissue samples, this technology delivers rapid, reliable data for your most demanding research.

Fig.1 UHPLC-MS/MS measured methylarginine standard curves.¹

• Comprehensive Neurodegenerative Disease Models

Accelerate your studies on Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and more with our extensive range of disease models. We offer genetically engineered animal models, iPSC-derived neurons, and human brain slice models, providing versatile platforms for mechanism research and effective drug screening.

Neurochemistry Analytes

Neurochemical Profiling and Analysis: Neurotransmitters, Neuropeptides. Analysis of Concentrations, Interactions, and Modulation.

Assays	Analytes
Neurotransmitters Assay	Dopamine, Serotonin, Acetylcholine, Glutamate, GABA (Gamma-Aminobutyric Acid), Norepinephrine
Neurotransmitter Metabolites Assay	Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA)
Neuropeptides Assay	Substance P, Neuropeptide Y, Oxytocin
Hormones Assay	Cortisol, Thyroid Hormones (T3 and T4), Sex Hormones (Estrogen, Testosterone)
Enzymes and Transporters Assay	Monoamine Oxidase (MAO), Transporters (e.g., Dopamine Transporter, Serotonin Transporter)

Tailored Neurochemistry Solutions

From Design to Delivery. We offer comprehensive, customized experimental services to meet your specific research needs. Our flexible design approach allows us to create optimized plans for lead compound optimization, mechanism verification, and safety assessment. With rapid response to research challenges and full-chain support, we ensure your project's success.

Sample Types We Analyze

We handle a diverse array of samples, including brain tissue homogenates, cerebrospinal fluid (CSF), neuronal cell cultures, blood plasma/serum, microdialysis samples, urine and saliva, and animal model-derived samples, supporting both in vitro and in vivo studies.

Specialized Downstream Neurochemistry Services

• Neurotransmitter Detection Assay
• CNS-related Cellular Kinase Assay
• Dopamine & Glutamate Receptor Assay

Please contact us for customized solutions and details, and let us work together to promote breakthroughs in the treatment of neurological diseases!

Reference

1. Ahmetaj-Shala, Blerina, et al. "Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping." Scientific Reports 8.1 (2018): 13987. Distributed under Open Access license CC BY 4.0, without modification.