Background of Neurochemistry
Neurochemistry is the study of the properties, structures, functions, and reactions of neurochemicals that are produced by the nervous system. Neurochemicals are a class of endogenous neurotransmitters or neurotransmitter-regulating substances, including acetylcholine, oxytocin, glutamate, serotonin, dopamine, norepinephrine, etc., with significant regulatory roles in neurological activities. The study of neurochemistry plays an essential role in exploring the pathogenesis of neuropsychiatric disorders as well as identifying biomarkers of neurological diseases. As a result, the development of neurochemistry-based drugs is emerging as a promising treatment for a range of neurodegenerative diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, and so on. The physiological and pathological mechanisms of other neurological diseases, including neuropsychiatric diseases (such as autism, hyperactivity disorders, and epilepsy) and neurotraumatic diseases (such as stroke, traumatic brain injury, and spinal cord injury) could also be explained by neurochemistry investigations.
In drug development, to screen more accurate and sensitive drug candidates, we need reliable in vitro models and technologies to monitor the effects of compounds on the regulation of neurochemicals. For this purpose, Creative Biolabs has established an electrochemical platform that allows for comprehensive in vitro biological analysis of a wide range of neurotransmitters. We combine high performance liquid chromatography (HPLC) with multiple tools to synergistically enhance the accuracy and efficiency of the detection of neurochemicals. Using radioligand receptor binding techniques, also known as radioimmunoassay, neurochemical alterations that affect neurological processes can be monitored.
Tools of neurochemistry assay are as follows:
- Liquid chromatography-mass spectrometry (LC-MS)
- HPLC-electrochemical detection
- HPLC-fluorescence detection
- Radioimmunoassay (RIA)
In addition to the determination of drug efficacy on neurochemicals, for the detection of absorption, distribution, metabolism, and excretion of neurochemicals, the samples of neurochemistry assay we collect include from cerebrospinal fluid (CSF) samples, brain tissue samples, and microdialysates, to plasma, urine, bone, gut, liver, kidney, and other organs.
We offer custom analyte services for specific neurochemicals, including but not limited to acetylcholine, amino acids (such as GABA, Tryptophan, and Serine), cAMP/cGMP, glucose and lactate, monoamines (such as dopamine and 5HT), polyamines, exogenous compounds, glucocorticoids.
In vitro neurochemistry assay offered by Creative Biolabs enables an extended understanding of the mechanisms of disease development and drug effects on neurochemicals. Our professional team offers you a customized solution for your drug development program dependent on your specific requirements, which can advance the progress of your drug development at the early stage. If you have the intention to learn more about neuroinflammation assays, please directly contact us. We are ready to answer questions about relevant expertise and help you to design your protocols.
For further details about neurochemistry assay, please check out the following link: