Alzheimer’s disease (AD) is a degenerative disease of the brain that causes dementia—a gradual loss of memory, judgment, and ability to function. It is named after Dr. Alois Alzheimer who noticed changes in the brain tissue of a woman that died of an unusual mental illness. Alzheimer’s is the most common cause of dementia among older adults, usually over the age of 65. The symptoms include problems with language, disorientation, mood swings, loss of motivation, lack of self-care, and behavioral issues.
The cause of Alzheimer's disease is poorly understood. Based on the reviews of twin and family studies, the genetic heritability of Alzheimer's disease ranges from 49% to 79%. Most of the autosomal dominant familial AD can be attributed to mutations in one of the three targets, amyloid precursor protein (APP), presenilins 1 and 2. The mutations in the APP and presenilin genes increase the production of a small protein called Aβ42, the main component of senile plaques.
Creative Biolabs offers a wide range of cutting-edge research products geared toward the investigation of biological processes underlying Alzheimer’s disease. Our products including cell lines, antibodies, antibody conjugates, proteins and small molecule activators and inhibitors, are among the bio-reagents keenly sought by neuroscience researchers.
Biological Processes and Targets Related to Alzheimer's Disease
|Positive Regulation of Apoptotic Process||UNC5C, PSEN1, MIR29B1, MIR29A, MIR146A|
|Positive Regulation of Cell Migration||PLAU, MIR29B1, MIR29A, CDKN2B-AS1|
|Cellular Response to Hypoxia||MIR34A, MIR146A, MIR106B|
|Response to Oxidative Stress||PSEN1, MPO, APP|
|Negative Regulation of Gene Expression||PSEN1, MIR29B1, MIR29A, MIR146A, CDKN2B-AS1, APP|
|Gene Silencing by miRNA||MIR34A, MIR328, MIR29B1, MIR29A, MIR146A, MIR107|
|Positive Regulation of Protein Binding||PSEN1, HFE APP|
|Negative Regulation of Angiogenesis||MIR34A, MIR29A, MIR146A, MIR106B|
|Negative Regulation of Protein Kinase B Signaling||MIR34A, MIR29B1, MIR29A, MIR146A|
|Positive Regulation of Cellular Senescence||MIR34A, MIR146A|