Alzheimer's Disease Related Research Tools
Alzheimer's disease (AD) is the most common form of dementia, a complex neurodegenerative brain disorder characterized by the progressive impairment of cognitive functions, particularly memory, thinking, language, mood, and behavioral issues.
AD is biologically defined by the presence of β-amyloid (Abeta) -containing plaques and tau-containing neurofibrillary tangles. Abeta plaques are formed by the aggregation of beta-amyloid peptides, which are fragments of a larger protein called amyloid precursor protein (APP).
Tau tangles, on the other hand, result from the abnormal phosphorylation and aggregation of tau protein, which is normally involved in maintaining the stability of microtubules within neurons. In Alzheimer's disease, tau protein forms twisted filaments called neurofibrillary tangles.
The accumulation of beta-amyloid plaques and tau tangles initiates a cascade of events that contribute to the progressive neurodegeneration observed in AD. This includes the activation of immune cells (microglia), inflammation, impairment of synaptic connections, and disruption of various signaling pathways in the brain.
As the disease progresses, affected individuals experience a decline in cognitive abilities, memory loss, disorientation, language difficulties, and changes in behavior and personality.
Biological Processes and Targets Related to Alzheimer's Disease
Biological processes | Targets |
Amyloid-beta plaques formation | APP, Aβ, PSEN1, PSEN2, B2M, Gal-3, AICD, BACE1, RAGE, ADAM, ApoE4, NEP, IDE, GSK-3 |
Neurofibrillary tangle formation | Tau, NF-kB, TNF-α, ILs, Cdc42, GSK-3β, CDK5, TPK-1, MARK, MAPK, AMPK, Dyrk1A, p53, PAC1R, ERK, CREB, CaMKII |
Neuroinflammation | TNF-α, TREM2, CD33, NF-κB, CD36, Calhm2, NLRP2, APOE, PGE2, IL-1, IL-2, IL-4, IL-1β, IL-6, IL-10, IFN-γ, TGF-β, SR-A, CR1, ABCA7, KMO, IFN-γ, P2X7R, TLR, CSF1R, miR-155, STAT3, CaSR, ABCA1, BACE1, Aqp4 |
Oxidative stress | NRF2, NADPH, PGC1α, miRNA-485, SIRT-1, PPAR-α |
Mitochondrial dysfunction | PGC1α |
Cholinergic insufficiency | AChE, BuChE, NGF |
Autophagy dysfunction | PKA, Drp-1, Parkin, mTOR, AMPK, LOX |
Neurovascular dysfunction | GLUT1, LRP1, P-gp, RAGE, CypA-MMP9 |
Synapse loss and alterations | NLRP3, RhoA, BDNF, PKCɛ, Jacob, NCAM, MAPK, ERK, NGF, ACSS2, CREB, NMDAR |
Ferroptosis | NRF2, GPX4, GSS |
Lipid dyshomeostasis | APOE, HMG-CoA, ACAT1 |
Genetic risk factor | APOE4, APP, PSEN1, PSEN2 |
Creative Biolabs offers a wide range of cutting-edge research products geared toward the investigation of biological processes underlying Alzheimer's disease. Our products including antibodies, cell lines, proteins & peptides, and assay kits, are among the bio-reagents keenly sought by neuroscience researchers.
Target







Alzheimer's disease
The Tau Aggregation kit is designed for the fast detection of human Tau aggregates in brain tissues and cell cultures.


Alzheimer's disease
The Amyloid β1-42 kit is designed for the simple and rapid quantification of the peptide in cell-based formats.


LRP1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-Fr; IHC-P; WB; ICC; IF; EM; DB; FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC


Rabbit Monoclonal Antibody to Alpha-synuclein (phospho S129)
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; DB; ELISA; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)