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Brain Neurohistology Assay

Nervous tissue in the nervous system controls and regulates the bodily functions and activities of almost all creatures through the ability to generate and transmit excitatory nerve impulses. Disorders of the nervous system, including the central nervous system and the peripheral nervous system, can lead to a series of neuromas, neurodegenerative diseases, and even rare diseases. Similarly, the study of such diseases is often inseparable from the corresponding experimental animal disease models and ex vivo research.

Histology analysis is the first step after constructing disease models and sampling tissues. This process symbolizes the development of your experiment from in vitro to ex vivo, from macroscopic observation of behavior to deep research of pathology, cell biology, and molecular biology. A complete and stable histology analysis can ensure the results of your complex front-end experiments and a good foundation for the success of your subsequent research.

With our rich experimental experience and cutting-edge theoretical basis, Creative Biolabs provides a full range of histology services from sample preparation to detailed and reliable research reports to customers around the world. For general histological analysis, our protocol is as follows:

Step 1 Samples Preparation

You can choose a specific standardized disease animal model for us to start the experiment directly, or you can hand over the treated experimental animal to our staff, we will carefully store and transport your precious sample, and handle it professionally.

Step 2 Dissection and Embedding

Our well-trained experimental team can dissect, trim, dehydrate, and embed your samples through standardized default procedures. Depending on your needs, we can adjust our procedures and choose the tissue of interest, the specified trimming surface, or an embedding material other than paraffin.

Step 3 Sectioning

Precise sectioning of brain tissue into thin slices is a critical step to obtain high-resolution images. Creative Biolabs employs advanced microtome technology to achieve consistent and ultra-thin sections.

Step 4 Staining and Imaging

Creative Biolabs' expertise lies in selecting antibodies with high specificity and affinity. Detection methods, including fluorescence and chromogenic detection, facilitate visualization under a microscope.

Step 5 Image Analysis

We use efficient software solutions to automatically analyze images for you to accurately and conveniently analyze the different characteristics of tissues in normal and pathological states. You can also select areas of interest or characteristic changes to allow us to provide you with more targeted data.

Sample Types

The Brain Neurohistology Assay's efficacy is amplified by the diverse range of sample types that can be employed, each offering unique insights into brain function and pathology.

Normal Brain Tissues: Comparative analysis of healthy brain tissues provides a baseline for understanding deviations associated with neurological disorders. Precise identification of cell types and their distribution aids in mapping neural circuits.
Diseased Tissues: Our brain neurohistology assays are pivotal in uncovering aberrant cellular changes linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. Characterizing protein aggregates and pathological markers contributes to disease diagnosis and potential therapeutic targets.

Customized Assay Development

Creative Biolabs' expertise in assay development extends to tailoring IHC techniques to the unique requirements of the research. For instance, our Immunofluorescence IHC assay offers multiplex staining capabilities, allowing simultaneous visualization of multiple biomarkers within a single tissue section. This is particularly valuable for studies focused on co-localization patterns and interaction between different neural components.

We welcome open communication to refine, enhance, or innovate testing methods in order to cater to diverse requirements. Feel free to contact us without hesitation. We are committed to offering viable solutions that align with your specific needs.

For Research Use Only. Not For Clinical Use.