Astrocyte Products

Astrocytes are the most abundant glial cells in the central nervous system (CNS). They undertake a wide range of homeostatic functions in the CNS, including buffering excess neurotransmitters, regulating synaptic and blood-brain barrier function, and supporting other cells resident in CNS. Whereas microglia serve as the cleaners and defenders of the brain, astrocytes ensure the brain runs quickly and efficiently. Emerging research indicates that dysfunction of astrocytes may play a crucial role in the pathogenesis of various neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease, amyotrophic lateral sclerosis, epilepsy and stroke.

Creative Biolabs offers a range of high-performance astrocytes tailored for in vitro assays, including primary astrocytes, immortalized astrocytes and human iPSC-derived astrocytes, aiming to provide you with comprehensive and accurate results. Please contact us to obtain astrocyte products or get support for related in vitro assays.

Product Overview

Access Creative Biolabs' latest ready to ship astrocytes of the following:

	Primary Astrocytes Human primary astrocytes derived from cerebral cortex, hippocampus, cerebellum, midbrain, brain stem, spinal cord or retina Mouse primary astrocytes derived from different brain regions of postnatal or embryonic CD1 (ICR) mouse or C57BL/6 mouse Rat primary astrocytes derived from different brain regions of postnatal or embryonic SD Rat
	Human iPSC-derived Astrocytes iNeu™ Astrocytes – Healthy Control iNeu™ Human Astrocytes - Alzheimer's Disease iNeu™ Human Astrocytes - Parkinson's Disease iNeu™ Human Astrocytes - Epilepsy iNeu™ Human Astrocytes - Autism Spectrum Disorder
	Immortalized Astrocytes Immortalized Human Astrocytes Immortalized Human Astrocytes with GFP

Applications

Distributed under Open Access license CC BY 3.0, from Wiki, without modification.	Drug Screening and Discovery Astrocytes from Creative Biolabs can be co-cultured with cortical neurons and microglia for drug screening platforms.		3D BBB Model Construction Astrocytes from Creative Biolabs can be co-cultured with brain endothelial cells and pericytes to construct 3D blood–brain barrier (BBB) model in vitro.
	Astrocyte Dysfunction Research Astrocytes from Creative Biolabs can be utilized to study the implications of astrocyte dysfunction in conditions such as AD and PD.		Anti-inflammatory Astrocytes from Creative Biolabs can be employed in screening anti-inflammatory compounds to restore homeostasis within the neural microenvironment.

Our Features & Advantages

Related Services

We are committed to supporting scientists around the world with the following astrocyte-related assays. Please contact us if you are interested.

References

1. Bai, Shunjie et al. "1H NMR-based metabolic profiling reveals the effects of fluoxetine on lipid and amino acid metabolism in astrocytes." Int J Mol Sci. 2015, 16(4):8490-8504.
2. Sonninen, Tuuli-Maria et al. "Metabolic alterations in Parkinson's disease astrocytes." Sci Rep. 2020, 10(1):14474.
3. Cibelli, Antonio et al. "Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice." Front Cell Neurosci. 2021, 15:647109.
4. Simöes Da Gama, Coraly, and Mélanie Morin-Brureau. "Study of BBB Dysregulation in Neuropathogenicity Using Integrative Human Model of Blood-Brain Barrier." Front Cell Neurosci. 2022, 16:863836.
5. Tcw, Julia, and Amaia M Arranz. "hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer's disease and potential therapeutics." Mol Neurodegener. 2023;18(1):19.
6. Linnerbauer, Mathias, and Veit Rothhammer. "Protective Functions of Reactive Astrocytes Following Central Nervous System Insult." Front Immunol. 2020;11:573256.
7. Distributed under Open Access license CC BY 4.0 without modification.