Product

Hot Products

Antibodies

Cells

Kits

Tracers

Gene Related Products

Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)
App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)

Biospecimens

Cell Assay Reagents

Guillain-Barré Syndrome Related Research Tools

Guillain-Barré syndrome (GBS), the most common cause of acute flaccid paralysis, is a rare condition in which a person’s immune system attacks the peripheral nerves. The symptoms of Guillain–Barré syndrome are numbness, tingling, pain and weakness of the legs and arms.

Guillain-Barré syndrome is due to the nerve dysfunction by an immune attack on the nerve cells of the peripheral nervous system. Different types of Guillain-Barré syndrome are categorized by different types of immune attack. For instance, the demyelinating variant is characterized by the damage to the myelin sheath from white blood cells preceded by the activation of a group of blood proteins. The axonal variant is mediated by the IgG antibodies and the complement components against the cell membrane covering the axons.

Fig.1 Immune system attacks nerves in the body with Guillain-Barre syndrome.

Creative Biolabs offers a series of research tools needed to study the mechanisms of Guillain-Barré syndrome. Some tools, such as autoimmune neuritis animal models, kinase enzymes and complement inhibitors, proteins and antibodies, have been verified in laboratory tests.

Pathways related to Guillain-Barre Syndrome

Super pathways	Genes
Measles	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, FAS
Herpes simplex virus 1 infection	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, FAS
Allograft rejection	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, FAS, CD40LG
NF-kappa B signaling	TNFRSF1B, TNF, FAS, CD79A, CD40LG
ICos-ICosL pathway in T-helper cell	HLA-DRB1, HLA-DQB1, HLA-DQA1, CD40LG

Cellular components related to Guillain-Barre Syndrome

Cellular components	Genes
External side of plasma membrane	TNF, MOG, HLA-DRB1, CD79A, CD40LG
Membrane raft	TNFRSF1B, TNF, FAS, CD79A
Endocytic vesicle membrane	HLA-DRB1, HLA-DQB1, HLA-DQA1
Myelin sheath	PMP2, MPZ, MBP

For Research Use Only. Not For Clinical Use.

Target

CD11b

LRRK2

CD339

APPL

SPOCK1

MECP2

DARPP32

Sarcoplasmic Reticulum

CrkL

IGF1 Receptor

APP

LIN7A

FABP4

FABP3

Myelin

PACRG

YY1

Synaptobrevin

COUP TF1

GFAP R416WT

PARD3

Gephyrin

GBA

Amyloid Beta

S100 Beta

IL-1α

HOMER3

PTPRN

Huntingtin

Afadin

CacyBP

GLP1

Related Products

NeuroMab™ Rabbit Anti-AFDN Monoclonal Antibody (CBP7284) [CAT#: NAB-0720-Z9912]

Afadin Rabbit Monoclonal Antibody

Host Species:: Rabbit

Species Reactivity:: Mouse; Rat; Human

Applications:: WB; IHC-P; IHC-Fr

Conjugation:: Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3546

Inquiry