Cell Viability and Cytotoxicity Assay
Detections of viability and cytotoxicity are pivotal indicators for the biological evaluation of studies. In vitro, some substances, especially drugs, have various mechanisms of cytotoxicity, such as damage to cell membranes, inhibition of protein synthesis as well as tight binding to specific receptors. To measure cell death caused by these injuries, specific methods and techniques are required. Creative Biolabs offers a variety of in vitro models for many diseases, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), and Amyotrophic Lateral Sclerosis (ALS). We are committed to providing best-in-class cell viability and toxicity testing services to customers around the world.
Overview of Cell Viability and Cytotoxicity Assay
There are many methods for measuring cell viability and cytotoxicity, which are mainly divided into the following categories: colorimetric assays, fluorometric assays, dye exclusion assays, and luminescence assays. In vitro assays have several merits, such as being fast, low-cost, and potential for automation, and no animals are required. Additionally, they are suitable for testing large numbers of samples. Cell viability and cytotoxicity assays rely on characterizing various cellular functions such as cell adhesion, cell membrane permeability, enzymatic activity, and nucleotide uptake activity.
Principle of Cell Viability and Cytotoxicity Assay
Ideal methods for in vitro viability and cytotoxicity assays should be efficient, reliable, safe, and cost-effective. The detection process should not affect the test compound. The choice of tissue or cell type assayed and detection method should be cautious. Different methods should be tried and compared before deciding on the final method. If possible, multiple assays should be combined to determine cytotoxicity and cell viability for in vitro studies to obtain more accurate results.
What Can We Do?
Despite decades of exploration and numerous advances, many neurodegenerative and systemic amyloid diseases have not been defined, nor have the pathogenic mechanisms that lead to cell death and disease been explored. In vitro cell viability and toxicity assays offer new prospects for the diseases. We can provide a variety of testing services, including but not limited to:
- AD In Vitro Assay
- PD In Vitro Assay
- HD In Vitro Assay
- ALS In Vitro Assay
- MS In Vitro Assay
- Oligodendrocyte Precursor Cell (OPC) Assay
- Neuron Assay
- Microglia Assay
- Astrocyte Assay
We can provide diverse in vitro models including but not limited to those listed below:
General Process of Our Service
Selecting the appropriate method is the basis for obtaining reliable results. Different factors such as test compound, detection mechanism, specificity and sensitivity must be considered when choosing a method. With years of experience, we can choose the most suitable method to advance your project according to your specific needs. Please contact us in time for more details.