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Biospecimens

Cell Assay Reagents

Encephalitis Related Research Tools

Encephalitis is an important cause of morbidity, mortality, and permanent neurologic sequelae globally. Causes are diverse and include viral and non-viral infections of the brain as well as autoimmune processes. The most common viral encephalitis agents are Japanese encephalitis virus (JEV), herpesviruses 1 and 2 (HSV-1 and HSV-2), and arbovirus. Other relevant etiologies are cytomegalovirus (CMV), seasonal influenza, Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), etc. The responsible virus may be detectable only in the brain and is either absent or transiently found in blood or cerebrospinal fluid (CSF). Autoimmune encephalitis (AIE) includes two major categories: classic paraneoplastic limbic encephalitis (LE) with autoantibodies against intracellular neuronal antigens such as Hu and Ma2 and new-type AIE with autoantibodies to the neuronal surface or synaptic antigens.

Fig.1 Signaling pathways involved in the recognition of HSV. (Piret, 2020)

For instance, herpes simplex encephalitis (HSE) is a severe neurological disease caused by HSV. Signaling pathways involved in the recognition of HSV are shown in Fig.1. TLR2, TLR3, TLR9 signaling pathways are essential for effective antiviral immunity in HSV infection. In the cytosol, viral dsDNA also induces the synthesis of Cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, cGAMP) by Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), which activates the STING/TRIF/TRAF3 signaling pathway. The popular targets are listed in the table below.

Summary of the Popular Targets in Encephalitis

Hu	Ma2	IL23
TLR3	TLR7	TLR9
TRIF	TBK1	STAT1
AMPAR receptor	NMDA receptor	GABAB1 receptor

Creative Biolabs provides a series of research tools and services needed to promote your research on encephalitis. Our product portfolio includes monoclonal antibodies (mAbs), polyclonal antibodies (pAbs), labeled antibodies, proteins, analytical kits, small molecule activators and inhibitors. For some targets, a ready-to-use catalog may not be available. Please contact us for customized services.

Reference

Piret, J.; Boivin G. Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis. Clinical Microbiology Reviews. 2020, 33(2).

For Research Use Only. Not For Clinical Use.

Target

NGF

Neurocan

WNT5A

Agrin

NeuroD1

UBE3A

HIP1

GFAP

TNFRSF9

CGRP

Mint-1

SOD2

GAD65

CD11b

PGD

Synaptogyrin 1

MAG

Cathepsin K

ATH

Neurofilament M

Proinsulin

ACT

Neurofilament L

ADAP1

Nicastrin

NSE

PROX1

TrkA

Laminin Gamma 1

HES1

TARDBP

nNOS

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NeuroMab™ Mouse Anti-CTSK Monoclonal Antibody (CBP7297) [CAT#: NAB-0720-Z9962]

Cathepsin K Mouse Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Rat; Human; Pig

Applications:: WB

Conjugation:: Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3558

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