Encephalitis Related Research Tools
Encephalitis is an important cause of morbidity, mortality, and permanent neurologic sequelae globally. Causes are diverse and include viral and non-viral infections of the brain as well as autoimmune processes. The most common viral encephalitis agents are Japanese encephalitis virus (JEV), herpesviruses 1 and 2 (HSV-1 and HSV-2), and arbovirus. Other relevant etiologies are cytomegalovirus (CMV), seasonal influenza, Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), etc. The responsible virus may be detectable only in the brain and is either absent or transiently found in blood or cerebrospinal fluid (CSF). Autoimmune encephalitis (AIE) includes two major categories: classic paraneoplastic limbic encephalitis (LE) with autoantibodies against intracellular neuronal antigens such as Hu and Ma2 and new-type AIE with autoantibodies to the neuronal surface or synaptic antigens.
Fig.1 Signaling pathways involved in the recognition of HSV. (Piret, 2020)
For instance, herpes simplex encephalitis (HSE) is a severe neurological disease caused by HSV. Signaling pathways involved in the recognition of HSV are shown in Fig.1. TLR2, TLR3, TLR9 signaling pathways are essential for effective antiviral immunity in HSV infection. In the cytosol, viral dsDNA also induces the synthesis of Cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, cGAMP) by Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), which activates the STING/TRIF/TRAF3 signaling pathway. The popular targets are listed in the table below.
Summary of the Popular Targets in Encephalitis
| Hu | Ma2 | IL23 |
| TLR3 | TLR7 | TLR9 |
| TRIF | TBK1 | STAT1 |
| AMPAR receptor | NMDA receptor | GABAB1 receptor |
Creative Biolabs provides a series of research tools and services needed to promote your research on encephalitis. Our product portfolio includes monoclonal antibodies (mAbs), polyclonal antibodies (pAbs), labeled antibodies, proteins, analytical kits, small molecule activators and inhibitors. For some targets, a ready-to-use catalog may not be available. Please contact us for customized services.
Reference
- Piret, J.; Boivin G. Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis. Clinical Microbiology Reviews. 2020, 33(2).
For Research Use Only. Not For Clinical Use.
Target
Premade Viruses
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iNeuMab™ Mouse Anti-CTSK Monoclonal Antibody (CBP7297) [CAT#: NAB-0720-Z9962]
Cathepsin K Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat; Human; Pig
- Applications:
- WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-NEFL Monoclonal Antibody (CBP7256) [CAT#: NAB-0720-Z9846]
68kDa Neurofilament/NF-L Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Rabbit; Cat; Human
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated
iNeuMab™ Rabbit Anti-CTSB Monoclonal Antibody (CBP7217) [CAT#: NAB-0720-Z9674]
Cathepsin B Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- FCM; IHC-P; WB; ICC; IF
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-Rat NEFM Monoclonal Antibody (CBP6927) [CAT#: NAB2109P281]
Anti-Neurofilament M Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- IF; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-MBP Monoclonal Antibody (CBP6602) [CAT#: NAB-1021-R0477]
Mouse monoclonal to MBP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-GLT1 Monoclonal Antibody (CBP6308) [CAT#: NAB-1021-R0166]
Mouse monoclonal to GLT1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-ATH Monoclonal Antibody (CBP6108) [CAT#: NAB-2106-S03]
Anti-Chicken Avian Thymic Hormone (ATH) Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Chicken
- Applications:
- ELISA; WB; IF
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-SOD2 Monoclonal Antibody (CBP6062) [CAT#: NAB-0421-R0676]
Mouse monoclonal to SOD2
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ELISA; IHC
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-SNCA Monoclonal Antibody (CBP6021) [CAT#: NAB-0421-R0493]
Mouse monoclonal to SNCA
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-FABP3 Monoclonal Antibody (CBP5979) [CAT#: NAB-0421-R0364]
Mouse monoclonal to FABP3
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-NEFL Monoclonal Antibody (CBP5949) [CAT#: NAB-0421-R0310]
Mouse monoclonal to NEFL
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-NSE Monoclonal Antibody (CBP5920) [CAT#: NAB-0421-R0239]
Mouse monoclonal to NSE
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- IHC; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-GFAP Monoclonal Antibody (CBP5884) [CAT#: NAB-0421-R0141]
Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-GFAP Monoclonal Antibody (CBP5858) [CAT#: NAB-0421-R0104]
Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IF; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-UCHL1 Monoclonal Antibody (CBP5831) [CAT#: NAB-0421-R0022]
Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-MSR1 Monoclonal Antibody (CBP5337) [CAT#: NAB-0321-R0818]
Mouse Monoclonal to MSR1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-ACT Monoclonal Antibody (CBP5281) [CAT#: NAB-0321-R0631]
Mouse Monoclonal to ACT
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
iNeuMab™ Mouse Anti-CLCN6 Monoclonal Antibody (CBP5234) [CAT#: NAB-0321-R0127]
Mouse Monoclonal to CLCN6
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
iNeuMab™ Mouse Anti-X11 Monoclonal Antibody (CBP5206) [CAT#: NAB-2103-P1099]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-Trk Monoclonal Antibody (CBP5175) [CAT#: NAB-2103-P1032]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; IHC-P; ELISA
iNeuMab™ Mouse Anti-Synaptogyrin Monoclonal Antibody (CBP5134) [CAT#: NAB-2103-P973]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-SMN Monoclonal Antibody (CBP5101) [CAT#: NAB-2103-P924]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-RAI Monoclonal Antibody (CBP5061) [CAT#: NAB-2103-P846]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-PGD Monoclonal Antibody (CBP5025) [CAT#: NAB-2103-P777]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-NTR Monoclonal Antibody (CBP4990) [CAT#: NAB-2103-P723]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-Nicastrin Monoclonal Antibody (CBP4956) [CAT#: NAB-2103-P672]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human; Canine
- Applications:
- WB; IP
iNeuMab™ Mouse Anti-NF Monoclonal Antibody (CBP4922) [CAT#: NAB-2103-P611]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-Neurocan Monoclonal Antibody (CBP4894) [CAT#: NAB-2103-P570]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-NALP Monoclonal Antibody (CBP4864) [CAT#: NAB-2103-P515]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-MAG Monoclonal Antibody (CBP4829) [CAT#: NAB-2103-P465]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
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