Somatosensory System Related Research Reagents
The somatosensory system is part of the sensory nervous system, which is a complex system of sensory neurons and neural pathways that respond to changes on the surface or in the body. The axons (as afferent nerve fibers) of sensory neurons connect with or respond to various receptor cells. These sensory receptor cells are activated by different stimuli (such as heat and nociception) and give functions to the responding sensory neurons (such as thermoreceptors that carry information about temperature changes). Other types include mechanoreceptors, chemoreceptors, and nociceptors, which send signals along the sensory nerves to the spinal cord, where they can be processed by other sensory neurons and then passed to the brain for further processing. Sensory receptors are distributed throughout the body, including skin, epithelial tissue, muscles, bones and joints, internal organs and cardiovascular system.
Somatosensory Pathway
All incoming touch/vibration information rises through the spinal cord via the posterior (dorsal) column-medial lemma pathway. The somatosensory pathway usually has three neurons: first-order, second-order, and third-order.
First-order neurons are a type of pseudo-unipolar neurons, and their cell bodies are always located in the dorsal root ganglia of spinal nerves. If the somatosensory pathway is located in a part of the head and neck, and the cervical nerves are not covered, the primary neurons will be the trigeminal ganglia or other sensory cranial nerve ganglia.
The cell bodies of second-order neurons are located in the spinal cord or brain stem. The ascending axon of this neuron will cross (disappear) to the opposite side in the spinal cord or brain stem.
In the case of touch and certain types of pain, the cell bodies of third-order neurons are located in the ventral posterior nucleus of the thalamus and terminate in the central posterior parietal gyrus of the primary somatosensory cortex (or S1).
Fig.1 CNS processing of sensory information.
Clinical Significance
Somatosensory defects may be caused by peripheral neuropathy involving peripheral nerves in the somatosensory system. This may manifest as numbness or paresthesias.
Creative Biolabs provides a complete list of antibodies and protein products to help our customers better understand the interaction between the somatosensory system and the neurological diseases. With our easy-to-use guide below, choose the best marker tools you need for your research.
Target


Mouse Monoclonal Antibody to CX3CR1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P; WB; IHC-Fr
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Mouse Monoclonal Antibody to Substance P
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Guinea Porcine; Human
- Applications:
- IHC-P; ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

CX3CR1 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Nav1.8/SCN10A Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

GPCR TGR7 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Myelin Protein Zero Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Mu Opioid Receptor Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Substance P Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Porcineeon; Crab
- Applications:
- IHC-Fr; ICC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

NMUR2 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Substance P Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

GPCR MRGX2 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Peripherin Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Rabbit; Human
- Applications:
- WB; ICC; IF; IHC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Monoacylglycerol Lipase/MGL Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

NMDAR2B (phospho Y1070) Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

CX3CR1 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Substance P Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

PSD93 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat; Human
- Applications:
- WB; IHC-P; IHC-Fr; ICC; IF
- Conjugation:
- Unconjugated

GPCR TGR7 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

TRPM8 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Human
- Applications:
- ICC; WB
- Conjugation:
- Unconjugated

TRPV4 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

NMDAR2B Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Myelin Protein Zero Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

VR1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC-Fr; ICC; IF; FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

NMDAR2B Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- ICC; WB; IHC-P; FC
- Conjugation:
- Unconjugated

TRPV3 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; FC; ICC; IF; IHC-P
- Conjugation:
- Unconjugated

TRPV3 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- FC; WB; IHC-P; IHC-Fr; ICC; IF
- Conjugation:
- Unconjugated

PSD93 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

NMDAR2B (phospho S1303) Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- DB; WB; ICC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

NMDAR2B Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- FC; ICC; IF; WB; IP; IHC-P; IHC-Fr
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

Nav1.8/SCN10A Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human; Monkey
- Applications:
- ICC; IF; WB; IHC-P; IHC-Fr; ICC; FC
- Conjugation:
- Unconjugated
- iNeuMab™ Anti-Alpha Synuclein BBB Shuttle Antibody (NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P1683) (Cat#: NRP-0422-P1683)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Anti-pTau Antibody (NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- iNeuMab™ Anti-SEZ6 Antibody (NRP-0422-P517) (Cat#: NRP-0422-P517)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P1684) (Cat#: NRP-0422-P1684)
- iNeuMab™ Anti-CD20 Antibody (NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Immortalized Human Cerebral Microvascular Endothelial Cells (Cat#: NCL-2108-P020)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Rat Muller Cell (Cat#: NCL2110P040)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- iNeu™ Human Sensory Neurons (Cat#: NCL-2103-P62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA (Cat#: NTA-2012-ZP78)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)