Therapeutic Nanoplatform for Neurological Disorders

Major central nervous system (CNS) diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), etc. have posed major challenges to public health. However, due to restricted access to the blood-brain barrier (BBB), most of the newly proposed drugs failed to enter clinical approval. The latest developments in nanotechnology provide opportunities to overcome the above-mentioned challenges raised by the BBB.

At Creative Biolabs, we have an in-depth understanding of key areas where the combination of neuroscience and nanotechnology has revolutionized the entire industry. Based on our nanotechnology platform, we provide customized nanoparticle (NP) services covering a variety of nanoparticles, including liposomes, dendrimers, viral capsids, polymer nanoparticles, silicon nanoparticles and magnetic/metal nanoparticles. The innate strategy of brain drug delivery to achieve effective drug delivery runs through the above-mentioned challenges in BBB and CNS. These nanoparticle-based drug carriers enable effective drug delivery throughout the BBB, which is the aforementioned challenge in the treatment of neurological disorders.

Fig. 1 Schematic of the relationship between the two closely intertwined fields: nanotechnology and neuroscience.

Advantages of nanoparticles

Several basic characteristics and factors that make nanomaterials an ideal material for neuroscience:

• Nanomaterials reflect the surface properties of organic tissues, such as morphology and energy, more accurately than their traditional micron counterparts.
• Due to the small size of nanomaterials, nanomaterials have many advantageous properties, such as high surface area to volume ratio, versatility, delivery or targeting at specific locations, controlled release, and versatility for surface modification.

Therefore, nanomaterials can be used as carriers for drug delivery, neuroprotective strategies, stents for nerve regeneration and differentiation, neuroimaging methods and neurosurgery equipment.

Classification of our nanoparticle platforms

NPs usually do not exceed 100 nm in size and have been proposed as an interesting tool that may solve the unsolved problem of enhancing BBB drug delivery. Among different devices, nanoparticle (NPs) technology is developing rapidly.

Creative Biolabs provides different types of nanomaterials (organic/inorganic NP systems) that have been used in the field of nanoneuroscience, such as liposomes, dendrimers, viral capsids, polymer nanoparticles, silicon nanoparticles and magnetic/metal nanoparticles (Figure 2).

Fig.2 Schematic diagram of different types of nanoparticle-based platforms.

Emerging Applications of Nanomaterials in Neuroscience.

• Nanocarriers promote intracellular transport
• Nanomaterials can trigger cell and tissue responses
• Nanotechnology and various nanostructures in the research of nervous system diseases
• Nanomaterials for neurological diagnosis and treatment
• Used in neuropsychiatry and neurodevelopmental disorders
• Nanodevices and biomolecules for neuron nanoscale exploration
• Using the cytoskeleton as a nano-level information processor

Creative Biolabs provides customized NP design and preparation services for neurosicience researcher. If you are interested in our services, please send an email to contact us, and our team will get back to you as soon as possible.

For more featured NP design and preparation serivice, please browse the service below:

Neurotransmitter-derived Lipidoid-Doped Lipid Nanoparticle Technology

Reference

1. Kumar, A., Tan, A., Wong, J., Spagnoli, J. C., Lam, J., Blevins, B. D., ... & Liu, H. (2017). Nanotechnology for neuroscience: promising approaches for diagnostics, therapeutics and brain activity mapping. Advanced functional materials, 27(39), 1700489.