- NeuroMab™ Anti-EPHB2 Antibody,Clone NR1370P (Cat#: NRP-0422-P1220)
- NeuroMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- NeuroMab™ Anti-Tau Antibody,Clone NR3320P (Cat#: NRP-0422-P1760)
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody,Clone NR2660P (Cat#: NRP-0422-P867)
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody, Clone NR19 (Cat#: NRZP-1022-ZP4114)
- NeuroMab™ Anti-Tau Antibody,Clone NR2944P (Cat#: NRP-0422-P1684)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- NeuroMab™ Anti-Tau Antibody,Clone NR2946P (Cat#: NRP-0422-P1686)
- NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- NeuroMab™ Anti-pTau Antibody,Clone NR3595P (Cat#: NRP-0422-P1719)
- Human Hippocampal Neuron Cells HPPNCs (Cat#: NCL2110P106)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- C57 Brain Cortex Neurons [Mouse] (Cat#: NCC20-9PZ48)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- AAV2/2Retro-CAG-DIO-EGFP-2A-TetTox-pA [Neural Tracing] (Cat#: NTA-2012-ZP303)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- AAV2/9-hSyn-Flpo-EGFP-WPRE-pA (Cat#: NTA-2012-ZP149)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- PRV-CAG-EGFP (Cat#: NTA-2011-ZP14)
- ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, HIRMab-TNFR (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein, cTfRMAb-GDNF (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-IDS BBB Shuttle Protein, HIRMab-IDS (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, cTfRMAb-TNFR (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein, HIRMab-PON1 (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein, HIRMab-GDNF (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, cTfRMAb-IDUA (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, HIRMab-IDUA (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein, HIRMab-NAGLU (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein, HIRMab-SGSH (Cat#: NRZP-0423-ZP505)
Therapeutic Nanoplatform for Neurological Disorders
Major central nervous system (CNS) diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), etc. have posed major challenges to public health. However, due to restricted access to the blood-brain barrier (BBB), most of the newly proposed drugs failed to enter clinical approval. The latest developments in nanotechnology provide opportunities to overcome the above-mentioned challenges raised by the BBB.
At Creative Biolabs, we have an in-depth understanding of key areas where the combination of neuroscience and nanotechnology has revolutionized the entire industry. Based on our nanotechnology platform, we provide customized nanoparticle (NP) services covering a variety of nanoparticles, including liposomes, dendrimers, viral capsids, polymer nanoparticles, silicon nanoparticles and magnetic/metal nanoparticles. The innate strategy of brain drug delivery to achieve effective drug delivery runs through the above-mentioned challenges in BBB and CNS. These nanoparticle-based drug carriers enable effective drug delivery throughout the BBB, which is the aforementioned challenge in the treatment of neurological disorders.
Fig. 1 Schematic of the relationship between the two closely intertwined fields: nanotechnology and neuroscience.
Advantages of nanoparticles
Several basic characteristics and factors that make nanomaterials an ideal material for neuroscience:
- Nanomaterials reflect the surface properties of organic tissues, such as morphology and energy, more accurately than their traditional micron counterparts.
- Due to the small size of nanomaterials, nanomaterials have many advantageous properties, such as high surface area to volume ratio, versatility, delivery or targeting at specific locations, controlled release, and versatility for surface modification.
Therefore, nanomaterials can be used as carriers for drug delivery, neuroprotective strategies, stents for nerve regeneration and differentiation, neuroimaging methods and neurosurgery equipment.
Classification of our nanoparticle platforms
NPs usually do not exceed 100 nm in size and have been proposed as an interesting tool that may solve the unsolved problem of enhancing BBB drug delivery. Among different devices, nanoparticle (NPs) technology is developing rapidly.
Creative Biolabs provides different types of nanomaterials (organic/inorganic NP systems) that have been used in the field of nanoneuroscience, such as liposomes, dendrimers, viral capsids, polymer nanoparticles, silicon nanoparticles and magnetic/metal nanoparticles (Figure 2).
Fig.2 Schematic diagram of different types of nanoparticle-based platforms.
Emerging Applications of Nanomaterials in Neuroscience.
- Nanocarriers promote intracellular transport
- Nanomaterials can trigger cell and tissue responses
- Nanotechnology and various nanostructures in the research of nervous system diseases
- Nanomaterials for neurological diagnosis and treatment
- Used in neuropsychiatry and neurodevelopmental disorders
- Nanodevices and biomolecules for neuron nanoscale exploration
- Using the cytoskeleton as a nano-level information processor
Creative Biolabs provides customized NP design and preparation services for neurosicience researcher. If you are interested in our services, please send an email to contact us, and our team will get back to you as soon as possible.
For more featured NP design and preparation serivice, please browse the service below:
Neurotransmitter-derived Lipidoid-Doped Lipid Nanoparticle Technology
Reference
- Kumar, A., Tan, A., Wong, J., Spagnoli, J. C., Lam, J., Blevins, B. D., ... & Liu, H. (2017). Nanotechnology for neuroscience: promising approaches for diagnostics, therapeutics and brain activity mapping. Advanced functional materials, 27(39), 1700489.