Potassium Channel Research Reagents

Potassium ion channels are the most widely distributed type of ion channels and are found in almost all living organisms. They form potassium-selective pores across cell membranes. Potassium ion channels are present in most cell types and control a variety of cell functions such as cognition, muscle contraction and hormone secretion. Therefore, abnormal function of potassium channels may lead to diseases (such as diabetes) and life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

There are four main types of potassium channels:

Calcium-activated potassium channels - open in response to the presence of calcium ions.
Inwardly rectifying potassium channels - pass current (positive charge) in the inward direction (into the cell).
Tandem pore domain potassium channels - constitutively open or have a high degree of basic activation, such as "quiescent potassium channels" or "leak channels" that set the negative membrane potential of neurons.
Voltage-gated potassium channels - voltage-gated ion channels that can open or close in response to changes in transmembrane voltage.

Potassium channel classes & functions

Class	Subclasses	Function	Blockers	Activators
Calcium-activated	BK channel SK channel IK channel	inhibition in response to rising intracellular calcium	Charybdotoxin Iberiotoxin Apamin BKCa-specific GAL-021	EBIO NS309 CyPPA Flufenamic acid Meclofenamic acid Niflumic acid Nimesulide Rottlerin (mallotoxin) Tolfenamic acid
Inwardly rectifying	ROMK (Kir1.1) GPCR regulated (Kir3.x) ATP-sensitive (Kir6.x)	recycling and secretion of potassium in nephrons mediate the inhibitory effect of many GPCRs close when ATP is high to promote insulin secretion	Ifenprodil Cloperastine Tertiapin Tipepidine Acetohexamide Carbutamide Chlorpropamide Glibenclamide (glyburide) Glibornuride Glicaramide Gliclazide Glimepiride Glipizide	ML-297 (VU0456810) Bimakalim Cromakalim Diazoxide Levcromakalim Minoxidil Nicorandil Pinacidil
Tandem pore domain	TWIK (TWIK-1, TWIK-2, KCNK7) TREK (TREK-1, TREK-2) TASK (TASK-1, TASK-3, TASK-5) TALK (TASK-2, TALK-1, TALK-2) THIK (THIK-1, THIK-2) TRESK	Contribute to resting potential	Bupivacaine Quinidine 12-O-Tetradecanoylphorbol-13-acetate Arachidonic acid Fluoxetine Norfluoxetine Modulated by GPCR agonists and antagonists	Halothane Riluzole Volatile anaesthetics GPCR agonists and antagonists
Voltage-gated	hERG (Kv11.1) KvLQT1 (Kv7.1)	action potential repolarization limits the frequency of action potentials (disturbances cause dysrhythmia)	3,4-Diaminopyridine (amifampridine) 4-Aminopyridine (fampridine/dalfampridine) Bretylium Tetraethylammonium Ajmaline Amiodarone AmmTX3 Linopirdine Ssm spooky toxin	Flupirtine Retigabine (Kv7)

Creative Biolabs provides a variety of potassium channel blockers, which can prevent potassium ions from passing through the channels on the cell membrane, and are used to treat hypertension and epilepsy. Our product portfolio also includes a series of products for potassium channel receptors research, including monoclonal antibodies, labeled antibodies, proteins, assay kits, and small molecule activators and inhibitors.

Please browse the options to take a deeper look at the tools for your research needs.

For Research Use Only. Not For Clinical Use.

Target

Tandem Pore Domain Potassium Channel Research Reagents

KCNK3

Inwardly Rectifying Potassium Channel Research Reagents

IRK-2

KCNJ8

KCNJ4

KCNJ2

Voltage-gated Potassium Channel Research Reagents

KCNQ1

KCNC2

KCNQ4

KCNQ2

Calcium-activated Potassium Channel Research Reagents

SLICK

KCNT1

KCNMB3

KCNU1

KCNMB2

Inwardly Rectifying Potassium Channel Research Reagents

Voltage-gated Potassium Channel Research Reagents

Calcium-activated Potassium Channel Research Reagents

Related Products

Mouse Anti-Human KCNQ1 Monoclonal Antibody (CBP5756) [CAT#: NAB2105281SL]

Anti-KCNQ1 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: ELISA; WB; FC

Conjugation:: Unconjugated

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