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- A Brainwide Atlas of Synapses Across the Mouse Life Span
- A Circadian Rhythm-Gated Subcortical Pathway for Nighttime-Light-Induced Depressive-Like Behaviors in Mice
- A Functional Map for Diverse Forelimb Actions within Brainstem Circuitry
- A Recurrent GOF Mutation in CLCN6 Causes Early-Onset Neurodegeneration
- An Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques
- Antidepressant Actions of Ketamine Engage Cell-Specific Translation via eIF4E
- Applications of Machine Learning to Diagnosis and Treatment of Neurodegenerative Diseases
- Association of Klotho-VS Heterozygosity With Risk of AD in Individuals with APOE4
- Association of Symptoms of Depression With Cardiovascular Disease
- Association of Youth Depression With Somatic Diseases and Premature Death
- Astrocytes Phagocytose Adult Hippocampal Synapses for Circuit Homeostasis
- Base Editing Strategy Allows Insertion of the A673T Mutation in APP Gene to Prevent the Development of Alzheimer's Disease
- Bidirectional Perisomatic Inhibitory Plasticity of a Fos Neuronal Network
- Cell Type-Specific Lipid Storage Changes in Parkinson's Disease Patient Brains are Recapitulated by Experimental Glycolipid Disturbance
- Chi3l1/YKL-40 Is Controlled by the Astrocyte Circadian Clock and Regulates Neuroinflammation and Alzheimer's Disease Pathogenesis
- CLR01 Protects Dopaminergic Neurons In Vitro and in Mouse Models of Parkinson's Disease
- Cranial Suture Regeneration and Craniosynostosis
- Cryo-EM Structure of Islet Amyloid Polypeptide Fibrils Reveals Similarities with Amyloid-β Fibrils
- Depression in Individuals who Subsequently Develop Inflammatory Bowel Disease: A Population-Based Nested Case-Control Study
- Diabetes Medications and Risk of Parkinson's Disease: A Cohort Study of Patients with Diabetes
- Differential Attentional Control Mechanisms by Two Distinct Noradrenergic Coeruleo-Frontal Cortical Pathways
- Effects of Acute Sleep Loss on Diurnal Plasma Dynamics of CNS Health Biomarkers in Young Men
- Estrogen Receptor-α Expressing Neurons in the Ventrolateral VMH Regulate Glucose Balance
- Evidence-Based Prevention of Alzheimer's Disease: Systematic Review and Meta-Analysis of 243 Observational Prospective Studies and 153 Randomised Controlled Trials
- Flexible and Stretchable Opto-Electric Neural Interface for Low-Noise Electrocorticogram Recordings and Neuromodulation In Vivo
- Flexible Fiber Probe for Efficient Neural Stimulation and Detection
- Forelimb Movements Evoked by Optogenetic Stimulation of the Macaque Motor Cortex
- G3BPs Tether the TSC Complex to Lysosomes and Suppress mTORC1 Signaling
- GABAergic Signaling to Astrocytes in the Prefrontal Cortex Sustains Goal-Directed Behaviors
- HSP40 Proteins Use Class-Specific Regulation to Drive HSP70 Functional Diversity
- IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition
- Increased Dopamine Transmission and Adult Neurogenesis in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice
- Landscapes of Bacterial and Metabolic Signatures and Their Interaction in Major Depressive Disorders
- Large-Scale Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation
- M2 Cortex-Dorsolateral Striatum Stimulation Reverses Motor Symptoms and Synaptic Deficits in Huntington's Disease
- Manipulating Synthetic Optogenetic Odors Reveals the Coding Logic of Olfactory Perception
- mGlu2- and mGlu3- Allosteric Modulators Enhance Thalamocortical Transmission
- MIND and Mediterranean Diets Associated with Later Onset of PD
- Mitochondrial Damage-Associated Inflammation Highlights Biomarkers in PRKN/PINK1 Parkinsonism
- Molecular Dissection of Amyloid Disaggregation by Human HSP70
- N-3 Polyunsaturated Fatty Acids Promote Astrocyte Differentiation and Neurotrophin Production Independent of cAMP in Patient-Derived Neural Stem Cells
- Nanozyme Scavenging ROS for Prevention of Pathologic α-Synuclein Transmission in Parkinson's Disease
- Neuroblast Senescence in the Aged Brain Augments Natural Killer Cell Cytotoxicity Leading to Impaired Neurogenesis and Cognition
- NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans
- Noncanonical Transnitrosylation Network Contributes to Synapse Loss in Alzheimer's Disease
- Patterns of De Novo Tandem Repeat Mutations and Their Role in Autism
- Postnatal Connectomic Development of Inhibition in Mouse Barrel Cortex
- Regulation of Sleep Homeostasis Mediator Adenosine by Basal Forebrain Glutamatergic Neurons
- Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Ageing
- Severe Reactive Astrocytes Precipitate Pathological Hallmarks of Alzheimer's Disease via H2O2- Production
- Single-Nucleus Transcriptome Analysis Reveals Dysregulation of Angiogenic Endothelial Cells and Neuroprotective Glia in Alzheimer's Disease
- Small Molecule Cognitive Enhancer Reverses Age-Related Memory Decline in Mice
- STAT3 in the Dorsal Raphe Gates Behavioural Reactivity and Regulates Gene Networks Associated with Psychopathology
- Tau PTM Profiles Identify Patient Heterogeneity and Stages of AD
- The Innate Immunity Protein IFITM3 Modulates γ-Secretase in Alzheimer's Disease
- αS Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons
- β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
- A Novel and Accurate Full-Length HTT Mouse Model for Huntington's Disease
- Assessment of Neurovascular Coupling and Cortical Spreading Depression in Mixed Mouse Models of Atherosclerosis and Alzheimer's Disease
- BET1 Variants Establish Impaired Vesicular Transport as a Cause for Muscular Dystrophy with Epilepsy
- Blood-Based Biomarkers for Alzheimer's Disease
- Caldendrin and Myosin V Regulate Synaptic Spine Apparatus Localization via ER Stabilization in Dendritic Spines
- Comparative Study of Brain fMRI of Olfactory Stimulation in NMOSD and MS
- Cysteine String Protein Controls Two Routes of Export for Misfolded Huntingtin
- DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors
- Enrichment of SARM1 Alleles Encoding Variants with Constitutively Hyperactive Nadase in Patients with ALS and Other Motor Nerve Disorders
- Genome-Wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis
- Human ALS/FTD Brain Organoid Slice Cultures Display Distinct Early Astrocyte and Targetable Neuronal Pathology
- Learning and Attention Increase Visual Response Selectivity through Distinct Mechanisms
- Loss of TREM2 Rescues Hyperactivation of Microglia, But Not Lysosomal Deficits and Neurotoxicity in Models of Progranulin Deficiency
- Macrophages Transfer Mitochondria to Sensory Neurons to Resolve Inflammatory Pain
- Make War Not Love: The Neural Substrate Underlying a State-Dependent Switch in Female Social Behavior
- Microglial PD-1 Stimulation by Astrocytic PD-L1 Suppresses Neuroinflammation and Alzheimer's Disease Pathology
- Mouse Visual Cortex Areas Represent Perceptual and Semantic Features of Learned Visual Categories
- Myelinating Schwann Cells and Netrin-1 Control Intra-Nervous Vascularization of the Developing Mouse Sciatic Nerve
- Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from AD
- Neurotoxin-Mediated Potent Activation of the Axon Degeneration Regulator SARM1
- Postnatal Expression of the Lysine Methyltransferase SETD1B is Essential for Learning and the Regulation of Neuron-Enriched Genes
- Synaptic Targets of Photoreceptors Specialized to Detect Color and Skylight Polarization in Drosophila
- Serotonergic Neurons Translate Taste Detection into Internal Nutrient Regulation
- Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of AD
- The Preference for Sugar Over Sweetener Depends on a Gut Sensor Cell
- The SARS-CoV-2 Main Protease Mpro Causes Microvascular Brain Pathology by Cleaving NEMO in Brain Endothelial Cells
- Trans ε-Viniferin Decreases Amyloid Deposits with Greater Efficiency Than Resveratrol in an Alzheimer's Mouse Model
- Transcriptomic Taxonomy and Neurogenic Trajectories of Adult Human, Macaque, and Pig Hippocampal and Entorhinal Cells
Assessment of Neurovascular Coupling and Cortical Spreading Depression in Mixed Mouse Models of Atherosclerosis and Alzheimer's Disease
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including dementia. In this study, we examined cortical haemodynamics in mouse preparations that modelled Alzheimer's disease (J20-AD) and atherosclerosis (PCSK9-ATH) between 9 and 12 m of age. We report novel findings with atherosclerosis where neurovascular decline is characterised by significantly reduced blood volume, altered levels of oxyhaemoglobin and deoxyhaemoglobin, in addition to global neuroinflammation. In the comorbid mixed model (J20-PCSK9-MIX), we report a 3 x increase in hippocampal amyloid-beta plaques. A key finding was that cortical spreading depression (CSD) due to electrode insertion into the brain was worse in the diseased animals and led to a prolonged period of hypoxia. These findings suggest that systemic atherosclerosis can be detrimental to neurovascular health and that having cardiovascular comorbidities can exacerbate pre-existing Alzheimer's-related amyloid-plaques.
Reference
Shabir, O., Pendry, B., Lee, L., Eyre, B., Sharp, P. S., Rebollar, M. A., ... & Berwick, J. (2022). Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer's disease. Elife, 11, e68242.
For Research Use Only. Not For Clinical Use.
