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NeuN Antibodies in Neuroscience Research

Neuronal Nuclei (NeuN) antibodies are one of the key tools commonly used in neuroscience research. As an essential component of modern neuroscience, NeuN antibodies play a crucial role in staining mature neurons and studying neuronal development and differentiation.

Creative Biolabs provides insight into what NeuN antibodies are, their use in neuroscience research, and key considerations for selecting the right NeuN antibody for various experimental applications.

What are NeuN Antibodies?

NeuN is a protein expressed predominantly in post-mitotic neurons, making it a valuable marker for neuronal identification. Discovered and characterized in 1992, NeuN has since become a cornerstone in neuroscience research, aiding in the study of neuronal populations, neuronal differentiation, and neurodegenerative diseases.

NeuN antibodies are immunoglobulins specifically designed to target and bind with the NeuN protein. These antibodies are instrumental in detecting and visualizing neurons within tissue samples, providing researchers with the means to explore the anatomical distribution, density, and morphology of neurons in diverse experimental settings.

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Our NeuN antibodies offer many advantages for identifying mature neurons in cell cultures and tissue sections for applications ranging from immunofluorescence to flow cytometry. They can be used in combination with other cell type markers. Read the table below and click to learn more about our NeuN antibodies.

Cat. No Product Name Clonality Applications
NAB20101935CR NeuroMab™ Mouse Anti-NeuN Monoclonal Antibody Monoclonal IHC; IF; ELISA
NAB2007FY1484 Mouse Anti-FOX3/NeuN Monoclonal Antibody (CBP6623) Monoclonal WB; IF; IHC-P
NAB-BA-P1625 Rabbit Anti-NeuN Monoclonal Antibody (CBP7407) Monoclonal WB
NRZP-0522-ZP122 NeuroMab™ Anti-NeuN, Mouse Monoclonal Antibody, Clone 1B7 (CBP8760) Monoclonal ICC; IHC-Fr; WB
NRZP-0822-ZP726 NeuroMab™ Anti-RBFOX3/NeuN Antibody, Clone N18969P (CBP9176) Monoclonal WB; FC; FC-IC; ICC; IF; IHC; IHC-Fr; IHC-P
NRZP-0822-ZP911 NeuroMab™ Anti-RBFOX3/NeuN Antibody, Clone N21989P (CBP9250) Monoclonal WB; ELISA; FC; ICC; IF
NRZP-0822-ZP1265 NeuroMab™ Anti-RBFOX3/NeuN Antibody, Clone N20019P (CBP9521) Monoclonal WB; FC; ICC; IF; IHC; IHC-P
NRZP-0822-ZP1418 NeuroMab™ Anti-RBFOX3/NeuN Antibody, Clone N26827P (CBP9633) Monoclonal WB; ELISA; FC; ICC; IF
NRZP-0822-ZP4522 NeuroMab™ Anti-RBFOX3/NeuN Antibody, Clone N26056P (CBP11621) Monoclonal WB; IHC-P
NRZP-0922-ZP3469 NeuroMab™ Anti-NeuN Antibody, Clone N2521 (CBP14780) Monoclonal WB; IF; IHC
NRZP-0922-ZP3470 NeuroMab™ Anti-NeuN Antibody, Clone N1398 (CBP14781) Monoclonal WB; IF; IHC
NRZP-0922-ZP3471 NeuroMab™ Anti-NeuN Antibody, Clone N25114 (CBP14782) Monoclonal WB; IF
NRZP-1022-ZP2215 NeuroMab™ Anti-NeuN Antibody, Clone NRb350D3 (CBP17423) Monoclonal ICC; IHC; IHC-P
NRZP-0223-ZP1226 NeuroMab™ Mouse Anti-FOX3/NeuN Monoclonal Antibody, Clone NR1290P (CBP18913) Monoclonal WB; IHC
NAB-0720-Z3855 NeuroMab™ Rabbit Anti-NeuN Monoclonal Antibody (CBP991) Monoclonal WB; IHC-P; IHC-Fr; IP

Cells that Express and Do Not Express NeuN

NeuN expression is not ubiquitous in all cell types of the nervous system.

NeuN-positive cells:

  • Mature neurons
  • Pyramidal neurons

NeuN-negative cells:

  • Neurons in the dorsal cochlear nucleus
  • Sympathetic chain ganglion neurons
  • Cortical Cajal-Retzius neurons
  • Neurons of the inferior olive and dentate nuclei

Uses of NeuN Antibodies in Neuroscience Research

  • Neuronal Identification and Classification
    By selectively binding to NeuN protein, these antibodies enable researchers to distinguish neurons from other cell types in complex neural tissues. This capability is particularly valuable in studies aiming to understand the organization and diversity of neuronal populations within different brain regions.
  • Neuronal Density Assessment
    NeuN antibodies aid researchers in quantifying the number of neurons in specific brain regions. This quantitative information is essential for understanding variations in neural density across different brain regions and in response to various experimental conditions, contributing to our understanding of neuroanatomy and function.
  • Neuronal Development and Plasticity Studies
    The expression of NeuN is closely linked to the maturation and post-mitotic state of neurons. As such, NeuN antibodies are instrumental in studying neuronal development and neuronal plasticity assay.
  • Neurodegenerative Disease Research
    Aberrations in NeuN expression patterns can serve as indicators of neuronal damage or loss, providing researchers with insights into the pathological mechanisms underlying these conditions. Additionally, NeuN antibodies contribute to the development of diagnostic tools for the early detection of neurodegenerative diseases.
  • Functional Mapping of the Brain
    NeuN antibodies, by virtue of their specificity to neurons, assist researchers in mapping neuronal circuits, understanding connectivity patterns, and deciphering the neural basis of various cognitive functions and behaviors.

How to Select NeuN Antibodies

The selection of NeuN antibodies is a critical step in designing experiments that rely on the precise identification and characterization of neurons. Several key factors should be considered when choosing NeuN antibodies to ensure the reliability and reproducibility of experimental results.

  • Antibody Specificity. Validation data provided by the antibody supplier, including Western blots, immunohistochemistry, or immunofluorescence images, can offer insights into the antibody's specificity.
  • Sensitivity
  • Application Compatibility
  • Species Reactivity. Cross-reactivity across multiple species can be advantageous for studies involving animal models or comparative analyses.
  • Tissue Compatibility
  • Validation and Reproducibility

Our NeuN antibodies offer many advantages in neuronal staining, and advanced technology ensures specificity and reproducibility. To stay up-to-date with the latest products and research tools from Creative Biolabs, you can feel free to contact us.

For Research Use Only. Not For Clinical Use.
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