Epilepsy and Seizures Related Research Tools
The epilepsy is a chronic neurological disorder in which clusters of nerve cells in the brain signal abnormally and cause seizures. The syndromes include uncontrolled shaking movements (e.g. tonic-clonic seizure involving much of the body with loss of consciousness), shaking movements (e.g. focal seizure involving only part of the body with variable levels of consciousness) and subtle momentary loss of awareness (e.g. absence seizure).
Seizures can be conceptualized as a result of the imbalance between excitation (E) and inhibition (I) in the brain. The factors that alter E/I balance can be genetic or acquired. These factors vary from genes and subcellular signaling cascades to widespread neuronal circuits, such as abnormal synaptic connectivity in cortical dysplasia, abnormal GABA receptor subunits in Angelman syndrome, potassium channel mutations in Brief Fear of Negative Evaluation Scale (BFNE) and structural alteration of hippocampal circuitry following prolonged febrile seizures.
Fig.1 Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure.
Creative Biolabs provides all kinds of products that can be applied to neuroscientific research: the roles of genes versus acquired factors in seizure predisposition, how epilepsy develops and how to prevent the consequences of seizures. Our products include neural cell lines and specialty media, neural proteins and antibodies, cytokines, agonists and antagonists.
Pathways and Genes Related to Epilepsy and Seizures
Super pathways | Top Affiliating Genes |
Transmission across chemical synapses | KCNV2, KCNQ3, KCNJ9, KCNJ4, KCNJ3, KCNJ16 |
Oxytocin signaling pathway | KCNJ9, KCNJ4, KCNJ3, KCNJ12 |
GABA receptor activation | KCNJ9, KCNJ4, KCNJ3, KCNJ16, KCNJ15, KCNJ12 |
Potassium channels | KCNV2, KCNQ3, KCNJ9, KCNJ4, KCNJ3, KCNJ16 |
Cardiac conduction | SCN8A, SCN1B, SCN1A, CACNB4, ATP1A3 |
Sudden infant death syndrome susceptibility pathway | GABRA1, CHRNB2, CHRNA4, ATP1A3 |
Phase 0 - rapid depolarisation | SCN8A, SCN1B, SCN1A, CACNB4 |
Target


alpha Elastin Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IHC-P; IHC-Fr
- Conjugation:
- Unconjugated

VGluT1 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- ICC; IF; FCM; IHC-P; WB
- Conjugation:
- Unconjugated

Anti-Visinin-Like Protein 1 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IF; WB
- Conjugation:
- Unconjugated

Anti-Glucagon Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Swine
- Applications:
- IHC
- Conjugation:
- Unconjugated

Mouse monoclonal to NEFM
- Host Species:
- Mouse
- Species Reactivity:
- Avian; Mammal; Rat
- Applications:
- WB; IHC
- Conjugation:
- Unconjugated

Mouse monoclonal to CGRP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IF
- Conjugation:
- Unconjugated

Mouse monoclonal to Aβ42
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ELISA; Dot
- Conjugation:
- Unconjugated

Mouse monoclonal to HTT
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; IP
- Conjugation:
- Unconjugated

Mouse monoclonal to FABP3
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to FABP2
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to S100B
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human; Monkey; Mouse; Rat
- Applications:
- IF; IHC; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse Monoclonal to Bax
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB
- Conjugation:
- Unconjugated

Mouse Monoclonal to Amyloid Beta
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- FC; IF; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; IHC-P; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; IHC-P; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
- iNeuMab™ Anti-Amyloid Beta 1-15 Antibody (NRP-0422-P867) (Cat#: NRP-0422-P867)
- iNeuMab™ Anti-SEZ6 Antibody (NRP-0422-P515) (Cat#: NRP-0422-P515)
- iNeuMab™ Anti-EPHB2 Antibody (NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- iNeuMab™ Anti-FGFR1 Antibody (NRP-0422-P1244) (Cat#: NRP-0422-P1244)
- iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P1686) (Cat#: NRP-0422-P1686)
- iNeuMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody (NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- iNeuMab™ Anti-ApoC3 BBB Shuttle Antibody (NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- iNeuMab™ Anti-TREM2 Antibody (NRP-0422-P792) (Cat#: NRP-0422-P792)
- iNeuMab™ Anti-CD32b Antibody (NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Rat Muller Cell (Cat#: NCL2110P040)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA (Cat#: NTA-2012-ZP78)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)