Epilepsy and Seizures Related Research Tools
The epilepsy is a chronic neurological disorder in which clusters of nerve cells in the brain signal abnormally and cause seizures. The syndromes include uncontrolled shaking movements (e.g. tonic-clonic seizure involving much of the body with loss of consciousness), shaking movements (e.g. focal seizure involving only part of the body with variable levels of consciousness) and subtle momentary loss of awareness (e.g. absence seizure).
Seizures can be conceptualized as a result of the imbalance between excitation (E) and inhibition (I) in the brain. The factors that alter E/I balance can be genetic or acquired. These factors vary from genes and subcellular signaling cascades to widespread neuronal circuits, such as abnormal synaptic connectivity in cortical dysplasia, abnormal GABA receptor subunits in Angelman syndrome, potassium channel mutations in Brief Fear of Negative Evaluation Scale (BFNE) and structural alteration of hippocampal circuitry following prolonged febrile seizures.
Fig.1 Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure.
Creative Biolabs provides all kinds of products that can be applied to neuroscientific research: the roles of genes versus acquired factors in seizure predisposition, how epilepsy develops and how to prevent the consequences of seizures. Our products include neural cell lines and specialty media, neural proteins and antibodies, cytokines, agonists and antagonists.
Pathways and Genes Related to Epilepsy and Seizures
| Super pathways | Top Affiliating Genes |
| Transmission across chemical synapses | KCNV2, KCNQ3, KCNJ9, KCNJ4, KCNJ3, KCNJ16 |
| Oxytocin signaling pathway | KCNJ9, KCNJ4, KCNJ3, KCNJ12 |
| GABA receptor activation | KCNJ9, KCNJ4, KCNJ3, KCNJ16, KCNJ15, KCNJ12 |
| Potassium channels | KCNV2, KCNQ3, KCNJ9, KCNJ4, KCNJ3, KCNJ16 |
| Cardiac conduction | SCN8A, SCN1B, SCN1A, CACNB4, ATP1A3 |
| Sudden infant death syndrome susceptibility pathway | GABRA1, CHRNB2, CHRNA4, ATP1A3 |
| Phase 0 - rapid depolarisation | SCN8A, SCN1B, SCN1A, CACNB4 |
For Research Use Only. Not For Clinical Use.
Target
Premade Viruses
Loading...
iNeuMab™ Rabbit Anti-ELN Monoclonal Antibody (CBP7283) [CAT#: NAB-0720-Z9911]
alpha Elastin Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IHC-P; IHC-Fr
- Conjugation:
- Unconjugated
iNeuMab™ Rabbit Anti-SLC17A7 Monoclonal Antibody (CBP7234) [CAT#: NAB-0720-Z9706]
VGluT1 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- ICC; IF; FCM; IHC-P; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-Human VSNL1 Monoclonal Antibody (CBP6965) [CAT#: NAB2109P327]
Anti-Visinin-Like Protein 1 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IF; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-Swine GCG Monoclonal Antibody (CBP6875) [CAT#: NAB2109P197]
Anti-Glucagon Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Swine
- Applications:
- IHC
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-NEFM Monoclonal Antibody (CBP6466) [CAT#: NAB-1021-R0333]
Mouse monoclonal to NEFM
- Host Species:
- Mouse
- Species Reactivity:
- Avian; Mammal; Rat
- Applications:
- WB; IHC
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-CGRP Monoclonal Antibody (CBP6213) [CAT#: NAB-1021-R0068]
Mouse monoclonal to CGRP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IF
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-Aβ42 Monoclonal Antibody (CBP6077) [CAT#: NAB-0421-R0754]
Mouse monoclonal to Aβ42
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ELISA; Dot
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-HTT Monoclonal Antibody (CBP6049) [CAT#: NAB-0421-R0610]
Mouse monoclonal to HTT
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; IP
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-FABP3 Monoclonal Antibody (CBP5997) [CAT#: NAB-0421-R0402]
Mouse monoclonal to FABP3
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-FABP2 Monoclonal Antibody (CBP5966) [CAT#: NAB-0421-R0350]
Mouse monoclonal to FABP2
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-S100B Monoclonal Antibody (CBP5934) [CAT#: NAB-0421-R0281]
Mouse monoclonal to S100B
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-GFAP Monoclonal Antibody (CBP5896) [CAT#: NAB-0421-R0153]
Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-GFAP Monoclonal Antibody (CBP5870) [CAT#: NAB-0421-R0121]
Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human; Monkey; Mouse; Rat
- Applications:
- IF; IHC; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-UCHL1 Monoclonal Antibody (CBP5843) [CAT#: NAB-0421-R0036]
Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-UCHL1 Monoclonal Antibody (CBP5818) [CAT#: NAB-0421-R0009]
Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-Bax Monoclonal Antibody (CBP5306) [CAT#: NAB-0321-R0745]
Mouse Monoclonal to Bax
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-Amyloid Beta Monoclonal Antibody (CBP5255) [CAT#: NAB-0321-R0551]
Mouse Monoclonal to Amyloid Beta
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- FC; IF; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
iNeuMab™ Mouse Anti-X11 Monoclonal Antibody (CBP5218) [CAT#: NAB-2103-P1111]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-UNC45 Monoclonal Antibody (CBP5192) [CAT#: NAB-2103-P1071]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-Tachykinin Monoclonal Antibody (CBP5159) [CAT#: NAB-2103-P1011]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-Sarcoplasmic Reticulum Monoclonal Antibody (CBP5117) [CAT#: NAB-2103-P940]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; IHC-P; ELISA
iNeuMab™ Mouse Anti-SAP 97 Monoclonal Antibody (CBP5082) [CAT#: NAB-2103-P888]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-Presenilin Monoclonal Antibody (CBP5045) [CAT#: NAB-2103-P812]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-p55 Monoclonal Antibody (CBP5006) [CAT#: NAB-2103-P748]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-NORRIN Monoclonal Antibody (CBP4974) [CAT#: NAB-2103-P697]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-NF Monoclonal Antibody (CBP4938) [CAT#: NAB-2103-P628]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-neuroligin Monoclonal Antibody (CBP4908) [CAT#: NAB-2103-P590]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-Netrin G1 Monoclonal Antibody (CBP4878) [CAT#: NAB-2103-P542]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; IHC-P; ELISA
iNeuMab™ Mouse Anti-Munc Monoclonal Antibody (CBP4847) [CAT#: NAB-2103-P491]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IP; IF; ELISA
iNeuMab™ Mouse Anti-LIS Monoclonal Antibody (CBP4813) [CAT#: NAB-2103-P441]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA
Product
Hot Products
Antibodies
- NeuroMab™ Anti-CD32b Antibody(NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- NeuroMab™ Anti-GARP Antibody(NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1683) (Cat#: NRP-0422-P1683)
- NeuroMab™ Anti-EPHB2 Antibody(NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2293) (Cat#: NRP-0422-P2293)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- NeuroMab™ Anti-pTau Antibody(NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
More
Cells
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Green Fluorescent Alpha-synuclein SH-SY5Y Cell Line (Cat#: NCL2110P209)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
More
Kits
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
More
Tracers
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- pAAV-syn-jGCaMP8m-WPRE (Cat#: NTA-2106-P062)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- pAAV-syn-FLEX-jGCaMP8f-WPRE (Cat#: NTA-2106-P064)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
More
Gene Related Products
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
More
Biospecimens
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
More
Cell Assay Reagents
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
More
