Sodium Channel Research Reagents
Sodium channels are intact membrane proteins that can form membrane ion channels, allowing sodium ion to be conducted through the plasma membrane of cells. In excitable cells such as nerve cells, muscle cells, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Sodium channels are the molecular targets of drugs used to prevent acute pain and to treat arrhythmia, epilepsy, and bipolar disorder. Sodium channel blockers are also being developed for the treatment of chronic pain.
Sodium channels are classified according to their gating mechanism. There are two very different types:
Voltage-gated sodium channel (NaV): NaV opens by responding to membrane depolarization, allowing sodium to enter, and causing depolarization to propagate along the plasma membrane of nerves, muscles, and other electrically stimulated cells. NaV is present in the membrane of most excitable cells and exists as a heterodimer or heterotrimer in the form of 1α- and 1 or 2β-subunits. They play a role in many processes, such as feelings, emotions, thoughts and movements.
Epithelial sodium channel (ENaC): ENaC is present in the absorbent epithelium, such as the distal renal tubules, alveolar epithelium, and distal colon. It is responsible for sodium reabsorption. They exist in the form of heterotetramers of α-, β- and γ-subunits, mainly 2α:1β:1γ. ENaC is involved in various biological processes, including sodium homeostasis, salty taste, nociception, pain transduction, tactile and mechanical transduction.
Sodium ion channel research requires a series of scientific research products. Creative Biolabs has been devoted to the research and development of the most advanced reagents to assist ion channel research. Our product portfolio covers a complete list of sodium channel activators and blockers, monoclonal antibodies, labeled antibodies, proteins and assay kits.
Please browse the options to take a deeper look at the tools for your research needs.
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Mouse Anti-SCN5A Monoclonal Antibody (CBP708) [CAT#: NAB-0720-Z2720]
nNav1.5 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ICC; IF; WB; FC
- Conjugation:
- Unconjugated
Anti-NALCN Polyclonal Antibody [FITC]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- FITC
Mouse Monoclonal to Nav1.8
- Host Species:
- Mouse
- Species Reactivity:
- Human; Monkey; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; AM
- Conjugation:
- Unconjugated
Mouse Monoclonal to NALCN
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated
Mouse Monoclonal to ENaC alpha
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC
- Conjugation:
- Unconjugated
Mouse Monoclonal to ENaC alpha
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Mouse Monoclonal to Nav beta3
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated
Mouse Monoclonal to Nav beta2
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF
- Conjugation:
- Unconjugated
Mouse Monoclonal to ENaC Beta
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Mouse Monoclonal to ASIC1
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC; IF
- Conjugation:
- Unconjugated
Mouse Monoclonal to Nav1.7
- Host Species:
- Mouse
- Species Reactivity:
- Hamster; Human; Mouse; Rat
- Applications:
- WB; ICC; IF; IP; AM
- Conjugation:
- Unconjugated
HCN1 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
ASIC1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat; Human
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated
ASIC2 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
ATP1A3 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
ATP1A3 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- IP; WB; ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Stomatin Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; ICC; IF; IP; FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Nav1.7 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- ICC; IF; IP; IHC-P; IHC-Fr; FC
- Conjugation:
- Unconjugated
Stomatin Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; ICC; IF; IP; FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
HCN1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; IHC-Fr; IP; WB; ICC; IF; FC
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- Human Microglia Cell Line, Immortalized (Cat#: NCL-2108P38)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
