Sodium Channel Related Research Reagents
Sodium channels are intact membrane proteins that can form membrane ion channels, allowing sodium ion to be conducted through the plasma membrane of cells. In excitable cells such as nerve cells, muscle cells, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Sodium channels are the molecular targets of drugs used to prevent acute pain and to treat arrhythmia, epilepsy, and bipolar disorder. Sodium channel blockers are also being developed for the treatment of chronic pain.
Sodium channels are classified according to their gating mechanism. There are two very different types:
Voltage-gated sodium channel (NaV): NaV opens by responding to membrane depolarization, allowing sodium to enter, and causing depolarization to propagate along the plasma membrane of nerves, muscles, and other electrically stimulated cells. NaV is present in the membrane of most excitable cells and exists as a heterodimer or heterotrimer in the form of 1α- and 1 or 2β-subunits. They play a role in many processes, such as feelings, emotions, thoughts and movements.
Epithelial sodium channel (ENaC): ENaC is present in the absorbent epithelium, such as the distal renal tubules, alveolar epithelium, and distal colon. It is responsible for sodium reabsorption. They exist in the form of heterotetramers of α-, β- and γ-subunits, mainly 2α:1β:1γ. ENaC is involved in various biological processes, including sodium homeostasis, salty taste, nociception, pain transduction, tactile and mechanical transduction.
Sodium ion channel research requires a series of scientific research products. Creative Biolabs has been devoted to the research and development of the most advanced reagents to assist ion channel research. Our product portfolio covers a complete list of sodium channel activators and blockers, monoclonal antibodies, labeled antibodies, proteins and assay kits.
Please browse the options to take a deeper look at the tools for your research needs.
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Mouse Anti-SCN5A Monoclonal Antibody (CBP708) [CAT#: NAB-0720-Z2720]
nNav1.5 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ICC; IF; WB; FC
- Conjugation:
- Unconjugated
Anti-NALCN Polyclonal Antibody [FITC]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- FITC
Mouse Monoclonal [NS134-12] to Nav1.8
- Host Species:
- Mouse
- Species Reactivity:
- Human; Monkey; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; AM
- Conjugation:
- Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated
Mouse Monoclonal [NS187-7] to NALCN
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated
Mouse Monoclonal [14E10] to ENaC alpha
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC
- Conjugation:
- Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated
Mouse Monoclonal [2G4] to ENaC alpha
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC
Mouse Monoclonal [NS396-29] to Nav beta3
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated
Mouse Monoclonal [NS395-68] to Nav beta2
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF
- Conjugation:
- Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated
Mouse Monoclonal [16E4] to ENaC Beta
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB
Mouse Monoclonal [NS271-44] to ASIC1
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC; IF
- Conjugation:
- Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated
Mouse Monoclonal [NS68-6] to Nav1.7
- Host Species:
- Mouse
- Species Reactivity:
- Hamster; Human; Mouse; Rat
- Applications:
- WB; ICC; IF; IP; AM
- Conjugation:
- Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated
HCN1 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; WB
ASIC1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat; Human
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated
ASIC2 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
ATP1A3 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
ATP1A3 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- IP; WB; ICC; IF
Stomatin Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; ICC; IF; IP; FC
Nav1.7 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- ICC; IF; IP; IHC-P; IHC-Fr; FC
- Conjugation:
- Unconjugated
Stomatin Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; ICC; IF; IP; FC
HCN1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; IHC-Fr; IP; WB; ICC; IF; FC
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody(NRP-0422-P867) (Cat#: NRP-0422-P867)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P614) (Cat#: NRP-0422-P614)
- NeuroMab™ Anti-FGFR1 Antibody(NRP-0422-P1244) (Cat#: NRP-0422-P1244)
- NeuroMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody(NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
- NeuroMab™ Anti-CD20 Antibody(NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- NeuroMab™ Anti-GARP Antibody(NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- NeuroMab™ Anti-TNFα BBB Shuttle Antibody(NRZP-1022-ZP4105) (Cat#: NRZP-1022-ZP4105)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- PRV-CAG-EGFP (Cat#: NTA-2011-ZP14)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
