Ataxia Related Research Tools
Ataxia is a degenerative disease of the nervous system. It is a clinical manifestation indicating dysfunction of the parts of the nervous system that coordinates movement, such as the cerebellum. Ataxia can have an insidious onset with a chronic and progressive clinical course (e.g. spinocerebellar ataxias of genetic origin) or have an acute onset resulting from cerebellar infarction, hemorrhage, or infection. Ataxia usually manifests as:
- Lack of coordination
- Trouble eating and swallowing
- Slurred speech
- Difficulty in walking
- Eye movement abnormalities
- Deterioration of fine motor skills
- Tremors
- Gait abnormalities
- Heart problems
Fig.1 Mitochondrial pathophysiology in Friedreich's Ataxia.
Ataxia can be a symptom of a multisystemic disorder, and an underlying etiology needs to be investigated. Ongoing discoveries of genetic abnormalities suggest the possible relations to mitochondrial dysfunction, related protein misfolding, abnormal mechanisms of DNA repair, oxidative stress, and abnormalities in cytoskeletal proteins.
Creative Biolabs is committed to promoting neurology disorders’ research and has developed a series of products to study those treatable and reversible etiologies of Ataxia, especially those from potentially life-threatening causes. These products portfolio includes recombinant proteins, antibodies, analytical/diagnostic kits and other small molecules.
Pathways and Genes Related to Ataxia
Super Pathways | Top Affiliating Genes |
A Double-Strand Break Repair | XRCC1, TDP1, PNKP, LIG3, FEN1, ATM |
TCR Signaling | WASL, WAS, PIK3R5, CACNA1A, ATM, ACTA1 |
Chks in Checkpoint Regulation | XRCC1, PNKP, LIG3, FEN1, ATM |
G-protein Signaling RAC1 in Cellular Process | WASL, WASF1, WAS, PIK3R5, ACTA1 |
Iron Metabolism in Placenta | TFRC, ACO1 |
Mitochondrial Iron-sulfur Cluster Biogenesis | LYRM4, FXN |
Target


- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells

- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells

- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells

- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells

- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells

- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells

- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells

Galectin 7 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IP; IHC-P; ICC; FCM
- Conjugation:
- Unconjugated

Laminin alpha 4/LAMA4 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- ICC; IF; WB
- Conjugation:
- Unconjugated

Neuroligin 4 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; WB
- Conjugation:
- Unconjugated

Anti-Sodium-Iodide Symporter Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IF; WB; IHC
- Conjugation:
- Unconjugated

Anti-ATM pS1981 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IF; FCM; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to FABP3
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IHC-P; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to ATXN1
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ICC; IF; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to P-tau181
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse
- Applications:
- WB; ELISA; IHC
- Conjugation:
- Unconjugated

Mouse monoclonal to APEX1
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- FC; IF; IHC; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to FABP3
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse monoclonal to NEFL
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC
- Conjugation:
- Unconjugated

Mouse monoclonal to S100B
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IF; IHC; WB
- Conjugation:
- Unconjugated

Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated

Mouse Monoclonal to NEFM
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IF; WB
- Conjugation:
- Unconjugated

Mouse Monoclonal to Amyloid Beta
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; IHC-P

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP; IF; ELISA

- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human; Hamster
- Applications:
- WB; IP; IF; IHC-P; FC
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-GARP Antibody(NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1684) (Cat#: NRP-0422-P1684)
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody(NRP-0422-P867) (Cat#: NRP-0422-P867)
- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody(NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- NeuroMab™ Anti-GD2 Antibody(NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- NeuroMab™ Anti-CD32b Antibody(NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- NeuroMab™ Anti-pTau Antibody(NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Rat Muller Cell (Cat#: NCL2110P040)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)