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Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)

Biospecimens

Cell Assay Reagents

Ataxia Related Research Tools

Ataxia is a degenerative disease of the nervous system. It is a clinical manifestation indicating dysfunction of the parts of the nervous system that coordinates movement, such as the cerebellum. Ataxia can have an insidious onset with a chronic and progressive clinical course (e.g. spinocerebellar ataxias of genetic origin) or have an acute onset resulting from cerebellar infarction, hemorrhage, or infection. Ataxia usually manifests as:

Lack of coordination
Trouble eating and swallowing
Slurred speech
Difficulty in walking
Eye movement abnormalities
Deterioration of fine motor skills
Tremors
Gait abnormalities
Heart problems

Fig.1 Mitochondrial pathophysiology in Friedreich's Ataxia.

Ataxia can be a symptom of a multisystemic disorder, and an underlying etiology needs to be investigated. Ongoing discoveries of genetic abnormalities suggest the possible relations to mitochondrial dysfunction, related protein misfolding, abnormal mechanisms of DNA repair, oxidative stress, and abnormalities in cytoskeletal proteins.

Creative Biolabs is committed to promoting neurology disorders’ research and has developed a series of products to study those treatable and reversible etiologies of Ataxia, especially those from potentially life-threatening causes. These products portfolio includes recombinant proteins, antibodies, analytical/diagnostic kits and other small molecules.

Pathways and Genes Related to Ataxia

Super Pathways	Top Affiliating Genes
A Double-Strand Break Repair	XRCC1, TDP1, PNKP, LIG3, FEN1, ATM
TCR Signaling	WASL, WAS, PIK3R5, CACNA1A, ATM, ACTA1
Chks in Checkpoint Regulation	XRCC1, PNKP, LIG3, FEN1, ATM
G-protein Signaling RAC1 in Cellular Process	WASL, WASF1, WAS, PIK3R5, ACTA1
Iron Metabolism in Placenta	TFRC, ACO1
Mitochondrial Iron-sulfur Cluster Biogenesis	LYRM4, FXN

For Research Use Only. Not For Clinical Use.

Target

Amyloid Beta

NR2E3

Als2

APEX1

Alpha Synuclein

GFR

CrkL

LIM Kinase 1

Proinsulin

Orexin Receptor 2

Numb

Laminin alpha 4/LAMA4

Ataxin 1

NMBR

GFAP

STXBP2

VGlut1

TBK1

Tau

ROR1

CD111

FTO

DDAH2

Vasopressin

CD11b

NF2

Synaptophysin

SLC14A2

SAP102

Gemin 2

Dab1

Mint-1

Related Products

iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 3 (SCA3) Patient, Donor 64 [CAT#: NRZP-0622-ZP91]

Human iPSC-derived neural stem cells from patients with spinocerebellar ataxia type 2 (SCA2)

Species:: Human

Applications:: Cell Culture

Cell Types:: Neural Stem Cells

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