Ataxia Research Tools
Ataxia is a degenerative disease of the nervous system. It is a clinical manifestation indicating dysfunction of the parts of the nervous system that coordinates movement, such as the cerebellum. Ataxia can have an insidious onset with a chronic and progressive clinical course (e.g. spinocerebellar ataxias of genetic origin) or have an acute onset resulting from cerebellar infarction, hemorrhage, or infection. Ataxia usually manifests as:
- Lack of coordination
- Trouble eating and swallowing
- Slurred speech
- Difficulty in walking
- Eye movement abnormalities
- Deterioration of fine motor skills
- Tremors
- Gait abnormalities
- Heart problems
Ataxia can be a symptom of a multisystemic disorder, and an underlying etiology needs to be investigated. Ongoing discoveries of genetic abnormalities suggest the possible relations to mitochondrial dysfunction, related protein misfolding, abnormal mechanisms of DNA repair, oxidative stress, and abnormalities in cytoskeletal proteins.
Creative Biolabs is committed to promoting neurology disorders’ research and has developed a series of products to study those treatable and reversible etiologies of Ataxia, especially those from potentially life-threatening causes. These products portfolio includes recombinant proteins, antibodies, analytical/diagnostic kits and other small molecules.
Pathways and Genes Related to Ataxia
| Super Pathways | Top Affiliating Genes |
| A Double-Strand Break Repair | XRCC1, TDP1, PNKP, LIG3, FEN1, ATM |
| TCR Signaling | WASL, WAS, PIK3R5, CACNA1A, ATM, ACTA1 |
| Chks in Checkpoint Regulation | XRCC1, PNKP, LIG3, FEN1, ATM |
| G-protein Signaling RAC1 in Cellular Process | WASL, WASF1, WAS, PIK3R5, ACTA1 |
| Iron Metabolism in Placenta | TFRC, ACO1 |
| Mitochondrial Iron-sulfur Cluster Biogenesis | LYRM4, FXN |
For Research Use Only. Not For Clinical Use.
Target
Related Products
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iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 3 (SCA3) Patient, Donor 64 [CAT#: NRZP-0622-ZP91]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 6 (SCA6) Patient, Donor 63 [CAT#: NRZP-0622-ZP90]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 7 (SCA7) Patient, Donor 62 [CAT#: NRZP-0622-ZP89]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 2 (SCA2) Patient, Donor 56 [CAT#: NRZP-0622-ZP83]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
iNeu™ Human Neural Stem Cells - Friedreich's Ataxia (familial control) Patient, Donor 49 [CAT#: NRZP-0622-ZP76]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
iNeu™ Human Neural Stem Cells - Friedreich's Ataxia (control) Patient, Donor 48 [CAT#: NRZP-0622-ZP75]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
iNeu™ Human Neural Stem Cells - Friedreich's Ataxia Patient, Donor 44 [CAT#: NRZP-0622-ZP71]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
iNeuMab™ Rabbit Anti-LGALS7 Monoclonal Antibody (CBP7314) [CAT#: NAB-0720-Z10007]
Galectin 7 Rabbit Monoclonal Antibody
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- Rabbit
- Species Reactivity:
- Human
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- WB; IP; IHC-P; ICC; FCM
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- Unconjugated
iNeuMab™ Mouse Anti-LAMA4 Monoclonal Antibody (CBP7278) [CAT#: NAB-0720-Z9904]
Laminin alpha 4/LAMA4 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
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- ICC; IF; WB
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- Unconjugated
iNeuMab™ Mouse Anti-NLGN4X Monoclonal Antibody (CBP7227) [CAT#: NAB-0720-Z9689]
Neuroligin 4 Mouse Monoclonal Antibody
- Host Species:
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- Mouse; Rat; Human
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- IHC-P; WB
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iNeuMab™ Mouse Anti-Human SLC5A5 Monoclonal Antibody (CBP6956) [CAT#: NAB2109P316]
Anti-Sodium-Iodide Symporter Monoclonal Antibody
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- Mouse
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- IF; WB; IHC
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iNeuMab™ Mouse Anti-Human ATM Monoclonal Antibody (CBP6857) [CAT#: NAB2109P100]
Anti-ATM pS1981 Monoclonal Antibody
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- Human
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iNeuMab™ Mouse Anti-FABP3 Monoclonal Antibody (CBP6450) [CAT#: NAB-1021-R0317]
Mouse monoclonal to FABP3
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iNeuMab™ Mouse Anti-ATXN1 Monoclonal Antibody (CBP6182) [CAT#: NAB-1021-R0037]
Mouse monoclonal to ATXN1
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iNeuMab™ Mouse Anti-P-tau181 Monoclonal Antibody (CBP6072) [CAT#: NAB-0421-R0749]
Mouse monoclonal to P-tau181
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- Mouse
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- Human; Mouse
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- WB; ELISA; IHC
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-APEX1 Monoclonal Antibody (CBP6043) [CAT#: NAB-0421-R0601]
Mouse monoclonal to APEX1
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- Mouse
- Species Reactivity:
- Human; Mouse; Rat
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- FC; IF; IHC; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-FABP3 Monoclonal Antibody (CBP5987) [CAT#: NAB-0421-R0390]
Mouse monoclonal to FABP3
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- Mouse
- Species Reactivity:
- Human
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- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-NEFL Monoclonal Antibody (CBP5958) [CAT#: NAB-0421-R0335]
Mouse monoclonal to NEFL
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- Mouse
- Species Reactivity:
- Human; Mouse; Rat
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- IHC
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- Unconjugated
iNeuMab™ Mouse Anti-S100B Monoclonal Antibody (CBP5930) [CAT#: NAB-0421-R0277]
Mouse monoclonal to S100B
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- Mouse
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- Human; Mouse; Rat
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- ELISA
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- Unconjugated
iNeuMab™ Mouse Anti-GFAP Monoclonal Antibody (CBP5892) [CAT#: NAB-0421-R0149]
Mouse monoclonal to GFAP
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- Mouse
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- Human
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- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-GFAP Monoclonal Antibody (CBP5866) [CAT#: NAB-0421-R0115]
Mouse monoclonal to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IF; IHC; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-UCHL1 Monoclonal Antibody (CBP5839) [CAT#: NAB-0421-R0030]
Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
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- ELISA
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- Unconjugated
iNeuMab™ Mouse Anti-UCHL1 Monoclonal Antibody (CBP5814) [CAT#: NAB-0421-R0005]
Mouse monoclonal to UCHL1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-NEFM Monoclonal Antibody (CBP5298) [CAT#: NAB-0321-R0718]
Mouse Monoclonal to NEFM
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IF; WB
- Conjugation:
- Unconjugated
iNeuMab™ Mouse Anti-Amyloid Beta Monoclonal Antibody (CBP5250) [CAT#: NAB-0321-R0545]
Mouse Monoclonal to Amyloid Beta
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- Species Reactivity:
- Human; Mouse; Rat
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- IHC; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
iNeuMab™ Mouse Anti-X11 Monoclonal Antibody (CBP5214) [CAT#: NAB-2103-P1107]
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- Mouse; Rat; Human
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NoGeneST™ Gene Silencing siRNA Kit, COQ7 (Human/Mouse/Rat) [CAT#: NRYF-0725-XY1534]
Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
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NoGeneST™ Gene Silencing siRNA Kit, BCCIP (Human/Mouse/Rat) [CAT#: NRYF-0725-XY298]
Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
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NoGeneST™ Gene Silencing siRNA Kit, Grm1 (Human/Mouse/Rat) [CAT#: NRYF-0625-XY335]
Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
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- Gene Silencing
NoGeneST™ Gene Silencing siRNA Kit, Chek1 (Human/Mouse/Rat) [CAT#: NRYF-0625-XY233]
Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.
- Applications:
- Gene Silencing
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