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Creative Biolabs

Ataxia Related Research Tools

Ataxia is a degenerative disease of the nervous system. It is a clinical manifestation indicating dysfunction of the parts of the nervous system that coordinates movement, such as the cerebellum. Ataxia can have an insidious onset with a chronic and progressive clinical course (e.g. spinocerebellar ataxias of genetic origin) or have an acute onset resulting from cerebellar infarction, hemorrhage, or infection. Ataxia usually manifests as:

  • Lack of coordination
  • Trouble eating and swallowing
  • Slurred speech
  • Difficulty in walking
  • Eye movement abnormalities
  • Deterioration of fine motor skills
  • Tremors
  • Gait abnormalities
  • Heart problems

Fig.1 Mitochondrial pathophysiology in Friedreich's Ataxia.Fig.1 Mitochondrial pathophysiology in Friedreich's Ataxia.

Ataxia can be a symptom of a multisystemic disorder, and an underlying etiology needs to be investigated. Ongoing discoveries of genetic abnormalities suggest the possible relations to mitochondrial dysfunction, related protein misfolding, abnormal mechanisms of DNA repair, oxidative stress, and abnormalities in cytoskeletal proteins.

Creative Biolabs is committed to promoting neurology disorders’ research and has developed a series of products to study those treatable and reversible etiologies of Ataxia, especially those from potentially life-threatening causes. These products portfolio includes recombinant proteins, antibodies, analytical/diagnostic kits and other small molecules.

Pathways and Genes Related to Ataxia

Super Pathways Top Affiliating Genes
A Double-Strand Break Repair XRCC1, TDP1, PNKP, LIG3, FEN1, ATM
TCR Signaling WASL, WAS, PIK3R5, CACNA1A, ATM, ACTA1
Chks in Checkpoint Regulation XRCC1, PNKP, LIG3, FEN1, ATM
G-protein Signaling RAC1 in Cellular Process WASL, WASF1, WAS, PIK3R5, ACTA1
Iron Metabolism in Placenta TFRC, ACO1
Mitochondrial Iron-sulfur Cluster Biogenesis LYRM4, FXN
For Research Use Only. Not For Clinical Use.

Target

Related Products
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Human iPSC-derived neural stem cells from patients with spinocerebellar ataxia type 2 (SCA2)

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with spinocerebellar ataxia type 6 (SCA6)

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with spinocerebellar ataxia type 2 (SCA2)

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with spinocerebellar ataxia type 2 (SCA2)

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with Friedreich's ataxia

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with Friedreich's ataxia

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with Friedreich's ataxia

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Galectin 7 Rabbit Monoclonal Antibody

Host Species:
Rabbit
Species Reactivity:
Human
Applications:
WB; IP; IHC-P; ICC; FCM
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3566

Laminin alpha 4/LAMA4 Mouse Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
ICC; IF; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3541

Neuroligin 4 Mouse Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
IHC-P; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3516

Anti-Sodium-Iodide Symporter Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IF; WB; IHC
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3347

Anti-ATM pS1981 Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; IF; FCM; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3322

Mouse monoclonal to FABP3

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; IHC-P; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3297

Mouse monoclonal to ATXN1

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
ICC; IF; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3272

Mouse monoclonal to P-tau181

Host Species:
Mouse
Species Reactivity:
Human; Mouse
Applications:
WB; ELISA; IHC
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3247

Mouse monoclonal to APEX1

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
FC; IF; IHC; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3222

Mouse monoclonal to FABP3

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3197

Mouse monoclonal to NEFL

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
IHC
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3172

Mouse monoclonal to S100B

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3147

Mouse monoclonal to GFAP

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3122

Mouse monoclonal to GFAP

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
IF; IHC; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3097

Mouse monoclonal to UCHL1

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3072

Mouse monoclonal to UCHL1

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3047

Mouse Monoclonal to NEFM

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IF; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2940

Mouse Monoclonal to Amyloid Beta

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
IHC; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2915
Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
WB; IP; IF; ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2890
Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
WB; IP; IF; ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2865
Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
WB; IP; IF; IHC-P
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2840
Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
WB; IP; IF; ELISA
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2815
Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human; Hamster
Applications:
WB; IP; IF; IHC-P; FC
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2790
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