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Creative Biolabs

Amyotrophic Lateral Sclerosis Related Research Tools

Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of the neurons controlling voluntary muscles. It is also known as Lou Gehrig's disease, Charcot's disease or motor neurone disease (MND). Over 17,000 people are estimated to be living with ALS in the United States, more commonly in whites, males, and people over the age of 60. The ALS symptoms include stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.

ALS can be classified as familial or sporadic ALS. It has been shown that more than 20 genes are associated with familial ALS, of which four account for the majority of familial cases: C9orf72 (40%), SOD1 (20%), FUS (1-5%), and TARDBP (1-5%). Other genes include CHCHD10, SQSTM1, and TBK1. These genes can be grouped into three general categories: protein degradation, the cytoskeleton, and RNA processing.

Creative Biolabs offers a range of research reagents needed for ALS investigation. Our products include monoclonal antibodies, polyclonal antibodies, labeled antibodies, recombinant proteins, analytical kits, cell lines, small molecule activators and inhibitors.

Related Genes of Amyotrophic Lateral Sclerosis (ALS)

Related Genes
  • SOD1
  • TARDBP
  • FUS
  • VEGFA
  • SLC1A2
  • TNF
  • ALS2
  • LAMC2
  • MAPT
  • GFAP
  • IGF1
  • CASP3
  • GDNF
  • CSF2
  • IGFALS
  • BDNF
  • CNTF
  • TRH
  • CHAT
  • MOTOR NEURON DEGENERATION

Related Pathways of Amyotrophic Lateral Sclerosis (ALS)

Related Pathways
  • SOD1 Pathogenesis
  • Cell Death
  • Neuron Death
  • Aging
  • Neuroprotection
  • Regeneration
  • Reflex
  • Innervation
  • RNA Processing
  • Neurogenesis
  • Transport
  • Localization
  • Muscle Atrophy
  • Secretion
  • Translation
  • Cognition
  • Immune Response
  • Cell Proliferation
  • Autophagy
  • Programmed Cell Death
Amyotrophic Lateral Sclerosis (ALS) Assay Service
For Research Use Only. Not For Clinical Use.

Target

Related Products
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Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells
Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Galectin 3 Rabbit Monoclonal Antibody

Host Species:
Rabbit
Species Reactivity:
Mouse; Rat; Human
Applications:
ICC; IF; WB; FCM; IHC-P
Conjugation:
Unconjugated

Neurocan Mouse Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
ICC; IF; WB
Conjugation:
Unconjugated

VGluT1 Mouse Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
IHC-P; WB
Conjugation:
Unconjugated

Anti-Sodium-Iodide Symporter Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB
Conjugation:
Unconjugated

Anti-GGRP Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Rat
Applications:
ELISA; IF; WB; IHC; IP
Conjugation:
Unconjugated

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB; IF

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.

Applications:
Gene Silencing

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.

Applications:
Gene Silencing
Applications:
Reduces TDP-43 expression to investigate its role in RNA processing, protein aggregation, and motor neuron degeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Suitable for in vitro (motor neuron cultures) and in vivo (ALS mouse models) studies.
Applications:
Our FUS-ASO specifically targets the Fused in Sarcoma (FUS) protein, associated with Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). By reducing FUS expression, it helps researchers study its role in RNA processing, neuronal function, and neurodegeneration, advancing research towards effective treatments for these disorders.
Applications:
Our SOD1-ASO specifically targets Superoxide Dismutase 1 (SOD1), a gene associated with Amyotrophic Lateral Sclerosis (ALS). By reducing SOD1 expression, it helps researchers study the role of SOD1 in oxidative stress, neuronal apoptosis, and neurodegeneration, facilitating the discovery of effective treatments for ALS.
Applications:
Designed for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) research, our C9ORF72-ASO specifically targets the C9ORF72 gene. By inhibiting its abnormal expression, it helps scientists explore disease mechanisms, validate C9ORF72 as a therapeutic target, and accelerate the development of RNA-based treatments for these neurodegenerative disorders.
Evans Blue [CAT#: NRZP-0323-ZP269]

Diazoxide [CAT#: NRZP-0323-ZP268]

CNQX [CAT#: NRZP-0323-ZP267]

Relevant Diseases:
Ischemia
(S)-AMPA [CAT#: NRZP-0323-ZP266]

Relevant Diseases:
Amyotrophic Lateral Sclerosis
Relevant Diseases:
Amyotrophic Lateral Sclerosis
6-Diazo-5-oxo-L-norleucine [CAT#: NRZP-0323-ZP264]

Relevant Diseases:
Amyotrophic Lateral Sclerosis
Human C9ORF72 Assay Kit [CAT#: NRZP-1122-ZP51]

Human C9orf72 ELISA Kit [CAT#: NRZP-0722-ZP239]

For the quantitative determination of human uncharacterized protein C9orf72 (C9orf72) concentrations in serum, plasma, tissue homogenates, cell lysates.

For the quantitative determination of human TAR DNA-binding protein 43 (TARDBP/TDP43) concentrations in serum, plasma, cell culture supernates, cerebrospinal fluid (CSF).

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