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Amyotrophic Lateral Sclerosis Related Research Tools

Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of the neurons controlling voluntary muscles. It is also known as Lou Gehrig's disease, Charcot's disease or motor neurone disease (MND). Over 17,000 people are estimated to be living with ALS in the United States, more commonly in whites, males, and people over the age of 60. The ALS symptoms include stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.

ALS can be classified as familial or sporadic ALS. It has been shown that more than 20 genes are associated with familial ALS, of which four account for the majority of familial cases: C9orf72 (40%), SOD1 (20%), FUS (1-5%), and TARDBP (1-5%). Other genes include CHCHD10, SQSTM1, and TBK1. These genes can be grouped into three general categories: protein degradation, the cytoskeleton, and RNA processing.

Pathophysiology of ALS

Amyotrophic Lateral Sclerosis (ALS)

Creative Biolabs offers a range of research reagents needed for ALS investigation. Our products include monoclonal antibodies, polyclonal antibodies, labeled antibodies, recombinant proteins, analytical kits, cell lines, small molecule activators and inhibitors.

Related Genes of Amyotrophic Lateral Sclerosis (ALS)

Related Genes
  • SOD1
  • TARDBP
  • FUS
  • VEGFA
  • SLC1A2
  • TNF
  • ALS2
  • LAMC2
  • MAPT
  • GFAP
  • IGF1
  • CASP3
  • GDNF
  • CSF2
  • IGFALS
  • BDNF
  • CNTF
  • TRH
  • CHAT
  • MOTOR NEURON DEGENERATION

Related Pathways of Amyotrophic Lateral Sclerosis (ALS)

Related Pathways
  • SOD1 Pathogenesis
  • Cell Death
  • Neuron Death
  • Aging
  • Neuroprotection
  • Regeneration
  • Reflex
  • Innervation
  • RNA Processing
  • Neurogenesis
  • Transport
  • Localization
  • Muscle Atrophy
  • Secretion
  • Translation
  • Cognition
  • Immune Response
  • Cell Proliferation
  • Autophagy
  • Programmed Cell Death
Amyotrophic Lateral Sclerosis (ALS) Assay Service
For Research Use Only. Not For Clinical Use.

Target

Related Products
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Human iPSC-derived neural stem cells from patients with amyotrophic lateral sclerosis

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with amyotrophic lateral sclerosis

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with amyotrophic lateral sclerosis

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Human iPSC-derived neural stem cells from patients with frontotemporal dementia

Species:
Human
Applications:
Cell Culture
Cell Types:
Neural Stem Cells

Galectin 3 Rabbit Monoclonal Antibody

Host Species:
Rabbit
Species Reactivity:
Mouse; Rat; Human
Applications:
ICC; IF; WB; FCM; IHC-P
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3565

Neurocan Mouse Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
ICC; IF; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3540

VGluT1 Mouse Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Mouse; Rat; Human
Applications:
IHC-P; WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3515

Anti-Sodium-Iodide Symporter Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3346

Anti-GGRP Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Rat
Applications:
ELISA; IF; WB; IHC; IP
Conjugation:
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3321

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB; IF

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IF

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB
Evans Blue [CAT#: NRZP-0323-ZP269]

Diazoxide [CAT#: NRZP-0323-ZP268]

CNQX [CAT#: NRZP-0323-ZP267]

Relevant Diseases:
Ischemia
(S)-AMPA [CAT#: NRZP-0323-ZP266]

Relevant Diseases:
Amyotrophic Lateral Sclerosis
Relevant Diseases:
Amyotrophic Lateral Sclerosis
6-Diazo-5-oxo-L-norleucine [CAT#: NRZP-0323-ZP264]

Relevant Diseases:
Amyotrophic Lateral Sclerosis
INI-0602 [CAT#: NRZP-0323-ZP263]

Human C9ORF72 Assay Kit [CAT#: NRZP-1122-ZP51]

Human C9orf72 ELISA Kit [CAT#: NRZP-0722-ZP239]

For the quantitative determination of human uncharacterized protein C9orf72 (C9orf72) concentrations in serum, plasma, tissue homogenates, cell lysates.

For the quantitative determination of human TAR DNA-binding protein 43 (TARDBP/TDP43) concentrations in serum, plasma, cell culture supernates, cerebrospinal fluid (CSF).

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