Amyotrophic Lateral Sclerosis Related Research Tools
Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of the neurons controlling voluntary muscles. It is also known as Lou Gehrig's disease, Charcot's disease or motor neurone disease (MND). Over 17,000 people are estimated to be living with ALS in the United States, more commonly in whites, males, and people over the age of 60. The ALS symptoms include stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.
ALS can be classified as familial or sporadic ALS. It has been shown that more than 20 genes are associated with familial ALS, of which four account for the majority of familial cases: C9orf72 (40%), SOD1 (20%), FUS (1-5%), and TARDBP (1-5%). Other genes include CHCHD10, SQSTM1, and TBK1. These genes can be grouped into three general categories: protein degradation, the cytoskeleton, and RNA processing.
Pathophysiology of ALS
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Creative Biolabs offers a range of research reagents needed for ALS investigation. Our products include monoclonal antibodies, polyclonal antibodies, labeled antibodies, recombinant proteins, analytical kits, cell lines, small molecule activators and inhibitors.
Related Genes of Amyotrophic Lateral Sclerosis (ALS)
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Related Pathways of Amyotrophic Lateral Sclerosis (ALS)
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Target
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Human iPSC-derived neural stem cells from patients with amyotrophic lateral sclerosis
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
Human iPSC-derived neural stem cells from patients with frontotemporal dementia
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Neural Stem Cells
Galectin 3 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- ICC; IF; WB; FCM; IHC-P
Neurocan Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- ICC; IF; WB
VGluT1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; WB
Anti-Sodium-Iodide Symporter Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Anti-GGRP Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- ELISA; IF; WB; IHC; IP
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC; WB; IF
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IF
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC; WB
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC; WB
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC; WB
Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC
- Relevant Diseases:
- Ischemia
- Relevant Diseases:
- Amyotrophic Lateral Sclerosis
- Relevant Diseases:
- Amyotrophic Lateral Sclerosis
- Relevant Diseases:
- Amyotrophic Lateral Sclerosis
For the quantitative determination of human uncharacterized protein C9orf72 (C9orf72) concentrations in serum, plasma, tissue homogenates, cell lysates.
For the quantitative determination of human TAR DNA-binding protein 43 (TARDBP/TDP43) concentrations in serum, plasma, cell culture supernates, cerebrospinal fluid (CSF).
- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P614) (Cat#: NRP-0422-P614)
- NeuroMab™ Anti-TREM2 Antibody(NRP-0422-P792) (Cat#: NRP-0422-P792)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P515) (Cat#: NRP-0422-P515)
- NeuroMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody(NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P517) (Cat#: NRP-0422-P517)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
