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Amyotrophic Lateral Sclerosis Related Research Tools

Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of the neurons controlling voluntary muscles. It is also known as Lou Gehrig's disease, Charcot's disease or motor neurone disease (MND). Over 17,000 people are estimated to be living with ALS in the United States, more commonly in whites, males, and people over the age of 60. The ALS symptoms include stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.

ALS can be classified as familial or sporadic ALS. It has been shown that more than 20 genes are associated with familial ALS, of which four account for the majority of familial cases: C9orf72 (40%), SOD1 (20%), FUS (1-5%), and TARDBP (1-5%). Other genes include CHCHD10, SQSTM1, and TBK1. These genes can be grouped into three general categories: protein degradation, the cytoskeleton, and RNA processing.

Pathophysiology of ALS

Amyotrophic Lateral Sclerosis (ALS)

Creative Biolabs offers a range of research reagents needed for ALS investigation. Our products include monoclonal antibodies, polyclonal antibodies, labeled antibodies, recombinant proteins, analytical kits, cell lines, small molecule activators and inhibitors.

Related Genes of Amyotrophic Lateral Sclerosis (ALS)

Related Genes
SOD1 TARDBP FUS VEGFA SLC1A2 TNF ALS2	LAMC2 MAPT GFAP IGF1 CASP3 GDNF CSF2	IGFALS BDNF CNTF TRH CHAT MOTOR NEURON DEGENERATION

Related Pathways of Amyotrophic Lateral Sclerosis (ALS)

Related Pathways
SOD1 Pathogenesis Cell Death Neuron Death Aging Neuroprotection Regeneration Reflex Innervation RNA Processing Neurogenesis	Transport Localization Muscle Atrophy Secretion Translation Cognition Immune Response Cell Proliferation Autophagy Programmed Cell Death

Amyotrophic Lateral Sclerosis (ALS) Assay Service

For Research Use Only. Not For Clinical Use.

Target

Melatonin

ApoA4 (NT)

Mint-1

Als2

RGMA

Insulin Receptor Alpha

NEFM

Neurofilament L

Ubiquilin-2

GZMB

IL-7

Syntenin

SOX2

C9orf72

PINK1

plexin

TARDBP

ROBO4

TRPM4

GPCR GPR17

ATRX

AMF

Neuropeptide Y

NK-1R

IL17RA

CD163

ITGA4

S100A9

Il-1β

GDNF

GGRP

Related Products

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iNeu™ Human Neural Stem Cells - Amyotrophic Lateral Sclerosis (ALS) (unaffected) Patient, Donor 38 [CAT#: NRZP-0622-ZP65]

Human iPSC-derived neural stem cells from patients with amyotrophic lateral sclerosis

Species:: Human

Applications:: Cell Culture

Cell Types:: Neural Stem Cells

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iNeu™ Human Neural Stem Cells - Frontotemporal Dementia, ALS Patient, Donor 8 [CAT#: NRZP-0622-ZP35]

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Host Species:: Rabbit

Species Reactivity:: Mouse; Rat; Human

Applications:: ICC; IF; WB; FCM; IHC-P

Conjugation:: Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3565

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NeuroMab™ Mouse Anti-NCAN Monoclonal Antibody (CBP7277) [CAT#: NAB-0720-Z9903]

Neurocan Mouse Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Mouse; Rat; Human

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Conjugation:: Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3540

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VGluT1 Mouse Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Mouse; Rat; Human

Applications:: IHC-P; WB

Conjugation:: Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3515

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NeuroMab™ Mouse Anti-Human SLC5A5 Monoclonal Antibody (CBP6955) [CAT#: NAB2109P315]

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Host Species:: Mouse

Species Reactivity:: Rat

Applications:: ELISA; IF; WB; IHC; IP

Conjugation:: Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3321

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Mouse Anti-RGMA Monoclonal Antibody (CBP6848) [CAT#: NAB2007FY1797]

Alzheimer's disease (AD), amyotrophic lateral
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Alzheimer's disease (AD), amyotrophic lateral
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Host Species:: Mouse

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Mouse Anti-S100A9 Monoclonal Antibody (CBP6845) [CAT#: NAB2007FY1794]

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Mouse Anti-S100A8 Monoclonal Antibody (CBP6844) [CAT#: NAB2007FY1793]

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Mouse Anti-OPALIN Monoclonal Antibody (CBP6843) [CAT#: NAB2007FY1792]

Alzheimer's disease (AD), amyotrophic lateral
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Mouse Anti-OPALIN Monoclonal Antibody (CBP6842) [CAT#: NAB2007FY1791]

Alzheimer's disease (AD), amyotrophic lateral
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Mouse Anti-IL7 Monoclonal Antibody (CBP6841) [CAT#: NAB2007FY1790]

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Mouse Anti-HLA-DRA Monoclonal Antibody (CBP6838) [CAT#: NAB2007FY1787]

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Evans Blue [CAT#: NRZP-0323-ZP269]

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Diazoxide [CAT#: NRZP-0323-ZP268]

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CNQX [CAT#: NRZP-0323-ZP267]

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(S)-AMPA [CAT#: NRZP-0323-ZP266]

Relevant Diseases:: Amyotrophic Lateral Sclerosis

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(+/-)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid [CAT#: NRZP-0323-ZP265]

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Human C9orf72 ELISA Kit [CAT#: NRZP-0722-ZP239]

For the quantitative determination of human uncharacterized protein C9orf72 (C9orf72) concentrations in serum, plasma, tissue homogenates, cell lysates.

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Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA Kit [CAT#: NRZP-0722-ZP238]

For the quantitative determination of human TAR DNA-binding protein 43 (TARDBP/TDP43) concentrations in serum, plasma, cell culture supernates, cerebrospinal fluid (CSF).

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