Ligand-Gated Ion Channel Research Reagents
Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion channel proteins allowing ions to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
Mechanism
When a presynaptic neuron is excited, it releases neurotransmitters from the vesicle to the synaptic cleft. The neurotransmitter then binds to the receptors on the postsynaptic neuron. If these receptors are ligand-gated ion channels, the conformational changes that occur will open the ion channels, causing ions to flow through the cell membrane. In turn, this leads to depolarization (for excitatory receptor responses) or hyperpolarization (for suppressing responses).
Ligand-Gated Ion-channel Proteins
These receptor proteins usually consist of at least two different domains: a transmembrane domain including an ion pore and an extracellular domain including a ligand-binding site (allergic binding site). The function of this receptor located at the synapse is to directly and very quickly convert the chemical signal of the neurotransmitter released before the synapse into a post-synaptic electrical signal.
Generally, LICs are divided into three super-families that lack evolutionary relationships: cys-loop receptors, ionotropic glutamate receptors and ATP-gated channels.
| Super-families | Subfamilies | Class |
| Cys-loop receptors | Cationic cys-loop receptors | Serotonin (5-HT); Nicotinic acetylcholine (nAChR); Zinc-activated ion channel (ZAC) |
| Anionic cys-loop receptors | GABAA, Glycine (GlyR) | |
| Ionotropic glutamate receptors | AMPA, Kainate, NMDA | |
| ATP-gated channels | P2X, PIP2 |
The research of ligand-gated ion channels requires a series of scientific research products. Creative Biolabs has been devoted to the research and development of the most advanced reagents to assist ion channel research. Our product portfolio covers a complete list of ion-channel proteins activators and blockers, monoclonal antibodies, labeled antibodies, proteins and assay kits.
Please browse the options to take a deeper look at the tools for your research needs.
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AIP Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mammals
- Applications:
- IP; WB
- Conjugation:
- Unconjugated
ClC-2 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; WB
- Conjugation:
- Unconjugated
Connexin 32 / GJB1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated
MCK10/NEP Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC
- Conjugation:
- Unconjugated
ClC-5 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat; Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated
TRPM4 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Dog; Human; Monkey
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated
CLCNKB Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated
MLC1 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated
DDR2 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; WB; ELISA; ICC; IF; IHC-P
- Conjugation:
- Unconjugated
DDR2 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated
Connexin 32 / GJB1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
CLC3 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- FC; WB; IHC-P; ICC; IF
- Conjugation:
- Unconjugated
SLC31A1 / CTR1 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated
MCK10/NEP Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- ICC; IF; FC
- Conjugation:
- Unconjugated
HCN2 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
HCN2 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- IHC-P; IHC-Fr; WB; ICC; IF; IP
- Conjugation:
- Unconjugated
Connexin 32 / GJB1 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; FC; IHC-P
- Conjugation:
- Unconjugated
AIP Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated
GABRE Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat; Human
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated
GABA A Receptor alpha 5/GABRA5 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Human
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated
GABARAP + GABARAPL1 + GABARAPL3 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IP; WB
- Conjugation:
- Unconjugated
GABARAP Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Rat; Human
- Applications:
- ICC; WB; IHC-P; IP
- Conjugation:
- Unconjugated
GABARAP+GABARAPL1+GABARAPL2 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human; Silk worm
- Applications:
- FC; WB; IHC-P; ICC; IF
- Conjugation:
- Unconjugated
NR3B Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; FC
- Conjugation:
- Unconjugated
NMDAR2A Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ICC; IF; WB
- Conjugation:
- Unconjugated
NMDAR2A Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; IHC-Fr; ICC; IF; WB
- Conjugation:
- Unconjugated
GluN2C Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB
- Conjugation:
- Unconjugated
NMDAR2A Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB
- Conjugation:
- Unconjugated
GluN2C Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB
- Conjugation:
- Unconjugated
NMDAR2A Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Green Fluorescent Tau cell Line (Cat#: NCL2110P219)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
