- NeuroMab™ Anti-Tau Antibody,Clone NR3320P (Cat#: NRP-0422-P1760)
- NeuroMab™ Anti-Tau Antibody,Clone NR2218P (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-TNFα BBB Shuttle Antibody,Clone NR3088P (Cat#: NRZP-1022-ZP4105)
- NeuroMab™ Anti-Tau Antibody,Clone NR2944P (Cat#: NRP-0422-P1684)
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- NeuroMab™ Anti-SEZ6 Antibody, Clone NR28P (Cat#: NRP-0422-P515)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody,Clone NR1707P (Cat#: NRZP-1022-ZP4050)
- NeuroMab™ Anti-CD20 Antibody,Clone NR3021P (Cat#: NRP-0422-P1230)
- NeuroMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Human CMEC/D3 Cell Line, Blood-Brain Barrier Model (Cat#: NCL-2108-P020)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Rat Muller Cell (Cat#: NCL2110P040)
- Human Hippocampal Neuron Cells HPPNCs (Cat#: NCL2110P106)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Human Glioblastoma Cell Line SF126 (Cat#: NCL-2108P35)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- Dextran-CYanine5.5 (Cat#: NTA-2011-ZP118)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- pAAV-syn-jGCaMP8m-WPRE (Cat#: NTA-2106-P062)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-EPO BBB Shuttle Protein, HIRMab-EPO (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein, cTfRMAb-EPO (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, cTfRMAb-TNFR (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein, HIRMab-PON1 (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, cTfRMAb-IDUA (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein, HIRMab-SGSH (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-ASA BBB Shuttle Protein, HIRMab-ASA (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein, 8D3-IL-1RA (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-IDS BBB Shuttle Protein, HIRMab-IDS (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein, HIRMab-NAGLU (Cat#: NRZP-0423-ZP506)
Optogenetic Tools
Optogenetics is a cutting-edge technology that employs a blend of optical and genetic methodologies to manipulate the activity of specific neurons with precision. This technique involves the integration of light-sensitive proteins into cells via gene fusion, and the utilization of a light-controlled system to modulate neural activity. The activation or inhibition of these light-sensitive proteins can govern the opening and closing of ion channels on the cell membrane, thereby altering the voltage changes of the cell membrane, such as depolarization and hyperpolarization.
Light-responsive proteins can be classified into two primary categories: opsin-based photoreceptors and photosensitive proteins.
Optogenetic Tools for Neuron Activation
Opsin | Peak Activation | Advantages |
ChR2(H134R) | 470 nm | ChR2(H134R) is a mutant of ChR2. ChR2(H134R) can generate twice the photocurrent, but the channel switching speed is twice as slow as wild-type ChR2. |
ChETA | 470 nm | ChETA is a mutant of ChR2 with faster kinetics, and neurons can fire spikes at 200 Hz when stimulated by laser. |
oChIEF | 450 nm - 470 nm | oChIEF can respond to high-frequency light stimulation (-100 Hz) in some neurons, accelerating the speed of channel closure and reducing the rate of inactivation under continuous light stimulation. |
C1V1 | 540 nm - 560 nm | This type of channel protein is more conducive to two-photon excitation. It is suitable for two-photon experiments. |
Chronos | 500 nm – 530 nm | ShChR (Chronos) has high light sensitivity and fast switching kinetics. |
ChrimsonR | 590 nm – 600 nm | ChrimsonR is a K176R point mutation of CnChR1 (Chrimson), which increases the closing speed of the channel and is suitable for experiments with higher stimulation frequencies. |
Optogenetic Tools for Neuronal Inhibition
Opsin | Peak Activation | Advantages |
eNpHR3.0 | 589 nm | eNpHR3.0 has better cell membrane targeting, more sustained current, fast response time and sensitive response. |
Arch | ~ 566 nm | Arch can move positively charged protons from the interior of neurons to the extracellular environment, placing neurons in a hyperpolarized state. Under certain conditions, it can be used to increase intracellular pH or decrease extracellular matrix pH. |
Jaws | 632 nm | Jaws inhibit neuronal activity by causing an influx of chloride ions when exposed to red light. |
SwiChRca | 475 nm | The C1C2 chimera mutation C128A (SwiChR) can slow the closure of the channel, and the chloride channel is continuously activated by a single blue light, keeping the cells in an inhibited state. |
QuasAr2 | 640 nm | QuasAr2 has the advantages of improved brightness and voltage sensitivity, microsecond response, and no photocurrent generated. |
Please browse through our related products list of optogenetics to find the right optogenetic tools for your experiment.
Creative Biolabs provides an extensive array of optogenetic tools centered around opsin and photosensitive proteins. In addition, we also extend our services to the customization of Adeno-Associated Viruses (AAVs). Please feel free to reach out to us to expedite your optogenetic research.
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- Tracer Type:
- Optogenetics
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- Optogenetics
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- Tracer Type:
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- Optogenetic Switche
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Custom Vector Development Service
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
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Custom Vector Development Service
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
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Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
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Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-inhibition
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
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![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
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![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
![](static/images/product/product-icon-neural-tracers.png)
Optogenetics-activation
Ready-to-use AAV particles
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics