Oligodendrocyte Products

An essential glial cell type in the central nervous system (CNS), oligodendrocytes and Oligodendrocyte progenitor cells (OPCs) are principally in charge of myelin production and maintenance. In the CNS, OPCs wrap around axons to create an insulating myelin sheath, aid in the effective transmission of bioelectrical signals, and preserve and safeguard neurons' regular function. These cells are not only essential for the survival of neurons but also play an important role in neurodegenerative diseases such as multiple sclerosis (MS) and Alzheimer's disease (AD).

At Creative Biolabs, our OPCs products provide researchers with powerful tools for neuroscience research, enabling them to make breakthroughs in neurobiology. We offer a comprehensive range of OPCs products, including animal primary OPCs (from rats and mice), human primary OPCs, and human induced pluripotent stem cell (hiPSC)-derived OPCs. To learn more about our products or submit a project inquiry, please contact us today.

Product Overview

	Primary Oligodendrocytes Human Oligodendrocytes and Human Oligodendrocyte Precursor Cells Mouse and Rat Oligodendrocytes Mouse and Rat Oligodendrocyte Precursor Cells
	Human iPSC-derived Oligodendrocytes iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs)
	Immortalized Oligodendrocytes Rat Oligodendrocyte Precursor Cell CG4

Features & Benefits

• Source and Purity: Our OPCs are sourced from cerebral cortex tissue and undergo rigorous screening to ensure a purity of over 90%, free from HIV-1, HBV, HCV, and other viral and microbial contamination.
• Growth Characteristics: These cells exhibit adherent growth and are round or oval in shape, making them well-suited for a variety of experimental applications.
• Culture Conditions: It is recommended to use the oligodendrocyte-specific culture medium from Creative Biolabs and culture at 37°C and 5% CO₂ to ensure optimal growth.
• High-quality Assurance: Our OPCs are subjected to a rigorous MBP immunofluorescence staining testing process to guarantee the highest standards of quality and reliability.

Applications

• The development and screening of new drugs is a crucial aspect of the pharmaceutical industry. By simulating the differentiation and myelination process of OPCs, we can develop and screen drugs for the treatment of demyelinating and myelin damage diseases in vitro.
• Neural Repair: Additionally, OPCs have demonstrated efficacy in nerve regeneration following injury, particularly in the promotion of remyelination.

For further information or to place an order, please contact us. We offer professional technical support and consulting services to assist customers in optimizing the use of these cells for research purposes.

References

1. Moloney, Roisin A., et al. "Dual isolation of primary neurons and oligodendrocytes from guinea pig frontal cortex." Frontiers in cellular neuroscience 17 (2024): 1298685.
2. Yamashita, Tomoko, et al. "Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells." PLoS One 12.2 (2017): e0171947.
3. Lichvarova, Lucia, et al. "Parvalbumin expression in oligodendrocyte-like CG4 cells causes a reduction in mitochondrial volume, attenuation in reactive oxygen species production and a decrease in cell processes’ length and branching." Scientific reports 9.1 (2019): 10603.
4. Distributed under Open Access license CC BY 4.0 without modification.