NeuroMab™ Anti-FGFR1 BBB Shuttle Antibody, Clone R1MAb2
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; In Vitro; In Vivo; Agonist
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 shows the GAL-Elk1 luciferase assay in rat L6 cells. Cells were co-transfected with expression vectors for the indicated FGFR isoforms together with GAL-Elk1, SV40-Renilla luciferase and Gal-responsive firefly luciferase reporter genes.
Figure 2 shows food intake (left), body weight (middle) and blood glucose (right) in db/db mice after a single intraperitoneal injection of R1Mab2 or control IgG at a dose of 3 mpk on day 0. Control mice were pair fed (PF) with adjusted food intake until day 11. On day 11, the food intake of R1MAb2-treated mice returned to normal, so all mice were fed ad libitum after day 11 (AL). N=7～12. p<0.001.
Figure 3 shows a GAL-Elk based luciferase assay in HEK293 cells expressing FGFRlc to compare R1MAb2 and a DNA mutant of R1MAb2 (R1MAb2 DANA).
Figure 4 shows the body weight of db/db mice after a single intraperitoneal injection of the indicated doses of R1MAb2 (labeled 182.2), R1MAb3 (labeled 182.5), or control IgG (anti-Her2) (bottom).
Figure 5 shows ELISA measurement of binding of anti-FGFRl antibodies to purified FGFR ECD fragments.
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