NeuroMab™ Anti-GIT2 scaffold protein BBB Shuttle Antibody, Clone N83/48

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GIT2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 450-759 (C-terminus) of human GIT2 (also known as ARF GTPaseactivating protein, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, Cool-interacting tyrosine-phosphorylated protein 2 and CAT2, accession number Q14161) Mouse: 88% identity (263/298 amino acids identical)
<50% identity with GIT1

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N83/48

Applications

WB; IHC; IP; ICC

Application Notes

No cross-reactivity against GIT1

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GIT2

Official Name

GIT2

Full Name

GIT2

Alternative Names

GIT2; CAT-2; CAT2; PKL; GIT ArfGAP 2

Uniprot ID

Q14161

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of rat brain membranes (RBM) and COS cells transiently transfected with Flag-tagged GIT1 and GIT2 and untagged Kv2.1 plasmids and probed with N83/48 (left) and K89/41 (right) TC supe and with anti-Flag antibody (middle).