NeuroMab™ Anti-Histone H2A.Z/V BBB Shuttle Antibody, Clone N310/21

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-H2AFZ BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 116-128 (KSLIGKKGQQKTV) of human Histone H2A.Z (also known as H2A/z, H2AFZ and H2AZ, accession number P0C0S5)
Mouse: 100% identity (13/13 amino acids identical)
Rat: 100% identity (13/13 amino acids identical)
>90% identity (12/13 amino acids identical, all but most C-terminal V) with Histone H2A.V

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N310/21

Applications

ELISA; DB; ICC; WB

Application Notes

Does not cross-react with amino acids 114-126 (AVLLPKKTESHKA) of human Histone H2A2C, which has>60% identity with other human Histones H2A's (H2A2B, H2A3, H2A2A, H2A1, H2A1H, H2A1D, H2A1C, H2A1B, H2A1A, H2A1J, H2A.J and H2A.X);Cross-reactivity against Histone H2A.V not yet determined

Research Areas

Epigenetics

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

H2AFZ

Official Name

H2AFZ

Full Name

Histone H2A.Z/V

Alternative Names

Histone H2A.Z

Uniprot ID

P0C0S5

Product Pictures

Fig. 1 Serial dilutions of BSA-conjugated target and non-target peptides dotted onto membrane and probed with N310/21 TC supe (left) and a rabbit polyclonal antibody control (right).

Publications