Product
NeuroMab™ Anti-Kvβ2 potassium channel BBB Shuttle Antibody, Clone K17/70
[CAT#: NRZP-0423-ZP239]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Kv beta 2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-367 (full length) of rat Kvβ2 (accession number NP_034728)
Epitope mapped to within amino acids 17-22
Human: 98% identity (362/367)
Mouse=100% identity
Epitope mapped to within amino acids 17-22
Human: 98% identity (362/367)
Mouse=100% identity
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
K17/70
Applications
WB; IHC; IP; ICC
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
Kv beta 2
Official Name
KCNAB2
Full Name
Kvbeta2/KCNAB2 K+ channel
Alternative Names
KCNAB2; AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2; potassium voltage-gated channel subfamily A regulatory beta subunit 2
Uniprot ID
P62482
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
IB
Fig. 2 Immunoblot on adult mouse brain membranes from two wild-type (WT1,2) and Kvβ2 knockout (Kvβ2 KO) mice.
IHC
Fig. 3 Adult rat hippocampus immunohistochemistry.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
