NeuroMab™ Anti-Kv9.2 potassium channel BBB Shuttle Antibody, Clone N460/19

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNS2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 411-477 (cytoplasmic C-terminus) of mouse Kv9.2 (also known as Potassium voltage-gated channel subfamily S member 2, Delayed-rectifier K(+) channel alpha subunit 2, Kcns2 and KIAA1144, accession number O35174)
Rat: 100% identity (67/67 amino acids identical)
Human: 97% identity (65/67 amino acids identical)
<50% identity with Kv9.1/Kcns1 and Kv9.3/Kcns3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N460/19

Applications

WB; IHC; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNS2

Official Name

KCNS2

Full Name

Kv9.2 K+ channel

Alternative Names

Potassium Voltage-Gated Channel Modifier Subfamily S Member 2; Potassium Voltage-Gated Channel; Delayed-Rectifier; Subfamily S; Member 2; Delayed-Rectifier K(+) Channel Alpha Subunit 2; Voltage-Gated Potassium Channel Subunit Kv9.2; Potassium Voltage-Gated Channel; Modifier Subfamily S; Member 2; Potassium Voltage-Gated Channel Subfamily S Member 2; KIAA1144; KV9.2;