NeuroMab™ Anti-MPP8 BBB Shuttle Antibody, Clone N119/44

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-MPHOSPH8 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 50-120 (Chromo domain) of human MPP8 (also known as m-phase phosphoprotein 8 and MPHOSPH8, accession number NP_059990)
Rat: 92% identity (66/71 amino acids identical)
Mouse: 91% identity (65/71 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N119/44

Applications

WB; IHC; ICC

Research Areas

Epigenetics

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

MPHOSPH8

Official Name

MPHOSPH8

Full Name

MPP8

Alternative Names

MPHOSPH8; HSMPP8; TWA3; mpp8; M-phase phosphoprotein 8

Uniprot ID

NP_059990

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transfected with GFP-tagged MPP8 and untagged Kv2.1 plasmids and probed with N119/44 (left panel) and K89/34 (right panel) TC supe.