NeuroMab™ Anti-pan-Shank (SH3 and multiple ankyrin repeat domains protein) scaffold protein BBB Shuttle Antibody, Clone N23B/49

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Pan-Shank BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (accession number Q9QX74)
Human: 94% identity (213/226 amino acids identical)
Mouse: 97% identity (220/226 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N23B/49

Applications

WB; IHC; IP; ICC

Application Notes

Recognizes Shank1, Shank2 and Shank3

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Pan-Shank

Official Name

Pan-Shank

Full Name

Pan-Shank

Alternative Names

SHANK3; DEL22q13.3; PROSAP2; PSAP2; SCZD15; SPANK-2

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with Shank1, Shank2 or Shank3 plasmids and probed with N23B/49 TC supe or a lane loading control.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].