NeuroMab™ Anti-Siglec 7 Antibody, Clone 4E3
A functional antibody raised against Human, Cynomolgus Monkey, Mouse Siglec-7.
- Host Species:
- Mouse; Humanized
- Species Reactivity:
- Human; Cynomolgus Monkey; Mouse
- Applications:
- FC; ELISA; Block; In Vitro; In Vivo; Antagonist
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Low Endotoxin < 1 EU/mg
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Research Use Only
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Figure 1 shows FACS analysis of Siglec-7 antibody binding to human primary dendritic cells compared to isotype control.
The endpoint after 30 h was normalized to the isotype control (gray bars) and the percent aggregated TDP-43 was calculated for ACI-7069-633B12-AM (dashed gray bars). Mean ± SD of three independent experiments are shown and statistical differences between isotype control and ACI-7069-633B12-AM (IgG2a variant) were analyzed by Welch's t-test (*** p < 0.001).
Figure 2 Anti-Siglec-7 antibodies 4E3 and 10B5 can down-regulate the cell surface expression of Siglec-7 on primary human dendritic cells.
The endpoint after 30 h was normalized to the isotype control (gray bars) and the percent aggregated TDP-43 was calculated for ACI-7069-633B12-AM (dashed gray bars). Mean ± SD of three independent experiments are shown and statistical differences between isotype control and ACI-7069-633B12-AM (IgG2a variant) were analyzed by Welch's t-test (*** p < 0.001).
Figure 3 Anti-Siglec-7 antibodies 10B5 and 4E3 inhibit PD-L1 and PD-L2 (PD-1 ligand), B7-H3 (strong T cell checkpoint inhibitory MDSC surface substance), CD200R (inhibiting signaling receptor) and CD163 and CD206 (M2-type marker).
The endpoint after 30 h was normalized to the isotype control (gray bars) and the percent aggregated TDP-43 was calculated for ACI-7069-633B12-AM (dashed gray bars). Mean ± SD of three independent experiments are shown and statistical differences between isotype control and ACI-7069-633B12-AM (IgG2a variant) were analyzed by Welch's t-test (*** p < 0.001).
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