NeuroMab™ Anti-Transferrin Receptor BBB Shuttle Antibody, Clone NR228P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Clone Number

NR228P

Applications

WB; ELISA; In Vitro; Inhib

Relevant Diseases

Parkinson's Disease; Amyotrophic Lateral Sclerosis; Huntington's Disease; Multiple Sclerosis; Tumor

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

TransferrinReceptor

Official Name

TfR

Full Name

Transferrin Receptor

Alternative Names

CD71; TFR1

Product Pictures

ELISA

Figure 1 depicts the binding of hu7A4.v15, hu15G11.v5 and hu7G7.v1 to huTfR in the presence of 6.3 μΜ holo-Tf. Antibody binding to immobilized huTfR is shown in the presence (open symbols and dashed lines) or absence (closed symbols and solid lines) of 6.3 μM holo-Tf.

Figure 2 depicts the binding analysis of 15G11.v5 IgG and Fab Ala variants to cynomolgus and human TfR demonstrating the presence of Ala in CDR-L3 and CDR-H3 of each antibody assessed as IgG and IgG or Fab by ELISA binding The effect of mutations on affinity was analyzed by SPR for immobilized human or cynomolgus TfR.

Publications