Product
NeuroMab™ Anti-ZNF423 BBB Shuttle Antibody, Clone N328B/37
[CAT#: NRZP-0423-ZP478]
- Species Reactivity:
- Human; Mouse
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ZNF423 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-180 (N-terminus) of human ZNF423 (also known as Zinc finger protein 423, Smad- and Olf-interacting zinc finger protein, Early B-cell factor (EBF) associated zinc finger protein, KIAA0760, OAZ, Ebfaz, Nur12 and Zfp423, accession number Q2M1K9)
Mouse: 97% identity (171/176 amino acids identical)
Rat: 96% identity (169/176 amino acids identical)
>50% identity with ZNF521
Mouse: 97% identity (171/176 amino acids identical)
Rat: 96% identity (169/176 amino acids identical)
>50% identity with ZNF521
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N328B/37
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with ZNF521
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
ZNF423
Official Name
ZNF423
Full Name
ZNF423
Alternative Names
ZNF423; Ebfaz; JBTS19; NPHP14; OAZ; Roaz; ZFP423; Zfp104; hOAZ; zinc finger protein 423
Uniprot ID
Q2M1K9
Product Pictures
IB
Fig. 1 Immunoblot versus crude low-speed pellet fractions from adult rat brain (RBLSP) and neonate wild-type (WT) and nur12 (ZNF423 knockout or KO) mouse cerebella probed with N328B/37 (left) and K89/34 (right) TC supe.
IF
Fig. 2 Immunofluorescence staining of embryonic wild-type (WT) and nur12 (ZNF423 knockout) mouse cerebella probed with N328B/37 TC supe (red, arrow indicates non-background signal) and DAPI nuclear stain (blue).
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
