Product
Mouse Anti-MAPK8 / JNK1 Monoclonal Antibody (CBP1943)
[CAT#: NAB2007FY398]
Mouse Monoclonal [W0036] to MAPK8 / JNK1
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat
- Applications:
- WB
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Mouse anti-human MAPK8/JNK1 antibody recognizes mitogen-activated protein kinase 8, also known as JUN N-terminal kinase, c-Jun N-terminal kinase 1, mitogen-activated protein kinase 8 subtype JNK1 alpha1, mitogen Activated protein kinase 8 subtype JNK1 beta2 and stress-activated protein kinase 1c.
Mitogen-activated protein kinase 8 is encoded by the MAPK8/JNK1 gene and is a member of the MAP kinase family. MAP kinase acts as an integration point for a variety of biochemical signals and participates in a variety of cellular processes, such as proliferation, differentiation, transcriptional regulation and development. This kinase is activated by various cellular stimuli and targets specific transcription factors, and thus mediates immediate early gene expression in response to cellular stimuli. It was found that tumor necrosis factor-α (TNF-α) activation of this kinase is necessary for TNF-α-induced apoptosis. This kinase is also involved in ultraviolet radiation-induced apoptosis, which is thought to be related to the cell death pathway mediated by cytochrome c. Studies on MAPK8 mouse counterparts indicate that this kinase plays a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcription variants encoding different isoforms have been reported (provided by RefSeq, June 2013).
The mouse anti-human MAPK8/JNK1 antibody can detect a 44/52 kDa band. The antibody has been extensively validated by Western blot using whole cell lysates.
Mitogen-activated protein kinase 8 is encoded by the MAPK8/JNK1 gene and is a member of the MAP kinase family. MAP kinase acts as an integration point for a variety of biochemical signals and participates in a variety of cellular processes, such as proliferation, differentiation, transcriptional regulation and development. This kinase is activated by various cellular stimuli and targets specific transcription factors, and thus mediates immediate early gene expression in response to cellular stimuli. It was found that tumor necrosis factor-α (TNF-α) activation of this kinase is necessary for TNF-α-induced apoptosis. This kinase is also involved in ultraviolet radiation-induced apoptosis, which is thought to be related to the cell death pathway mediated by cytochrome c. Studies on MAPK8 mouse counterparts indicate that this kinase plays a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcription variants encoding different isoforms have been reported (provided by RefSeq, June 2013).
The mouse anti-human MAPK8/JNK1 antibody can detect a 44/52 kDa band. The antibody has been extensively validated by Western blot using whole cell lysates.
Immunogen
Recombinant protein derived from Escherichia coli, corresponding to aa 1-427 of human MAPK8 / JNK1
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP1943
Applications
WB
Application Notes
WB (1/1000)
Relevant Diseases
Lou Gehring's Disease
Research Areas
Neuroregeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS; 0.09% Sodium Azide
Preservatives
Yes
Purification
Affinity chromatography on Protein G from tissue culture supernatant.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
MAPK8
Official Name
MAPK8
Full Name
Mitogen-Activated Protein Kinase 8
Alternative Names
Mitogen-Activated Protein Kinase 8; Stress-Activated Protein Kinase 1c; C-Jun N-Terminal Kinase 1; JUN N-Terminal Kinase; MAP Kinase 8; EC 2.7.11.24; JNK-46; SAPK1c; PRKM8; SAPK1; JNK1
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
