Product
Mouse Anti-FBLN5 Monoclonal Antibody (CBP2609)
[CAT#: NAB20101683CR]
Mouse Monoclonal (2A5C8) to FBLN5
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat; Porcine
- Applications:
- IF; WB; ELISA
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Fibulin-5 is a extracellular matrix glycoprotein, secreted by various cell types such as vascular smooth muscle cells, fibroblasts and endothelial cells. Structurally, Fibulin-5 contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies. This antibody got 50 kDa or 66 kDa band in western blotting, the 66 kDa corresponding to fully glycosylated protein.
Expression Host
Mammalian cells
Immunogen
Fibulin 5 fusion protein Ag2859
Species Reactivity
Human; Mouse; Rat; Porcine
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP2609
Applications
IF; WB; ELISA
Application Notes
IF : 1:20-1:200; WB : 1:500-1:1000
Research Areas
Neuroendocrinology
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, 0.1% sodium azide and 50% glycerol pH 7.3.
Preservatives
Yes
Concentration
1200 μg/ml
Purification
Antigen affinity purification
Purity
>95%, as determined by SDS-PAGE
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at -20°C. Stable for one year after shipment.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Hulleman, J. D., Brown, S. J., Rosen, H., & Kelly, J. W. (2013). A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion. Journal of biomolecular screening, 18(6), 647-658. 2. Hwang, C. F., Shiu, L. Y., Su, L. J., Yin, Y. F., Wang, W. S., Huang, S. C.,... & Fang, F. M. (2013). Oncogenic fibulin-5 promotes nasopharyngeal carcinoma cell metastasis through the FLJ10540/AKT pathway and correlates with poor prognosis. PloS one, 8(12), e84218.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
