Product
NeuroMab™ Anti-GABA-A-R-Beta2/3, Clone 62-3G1 (CBP8216)
[CAT#: NRP-0422-P115]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Immunogen
Fraction of bovine brain GABA-A receptor affinity purified against immobilized benzodiazepine Ro7-1986/1. Target initially identified as a GABA-A receptor by:
-rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol
-immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex
-recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions
Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta3, accession number P28472)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical)
86% identity (13/15 amino acids identical, QSVNDPSNMSLVKET) with GABA-A-R-Beta2
66% identity (10/15 amino acids identical, HSTNEPSNMSYVKET) with GABA-A-R-Beta1
-rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol
-immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex
-recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions
Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta3, accession number P28472)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical)
86% identity (13/15 amino acids identical, QSVNDPSNMSLVKET) with GABA-A-R-Beta2
66% identity (10/15 amino acids identical, HSTNEPSNMSYVKET) with GABA-A-R-Beta1
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
CBP8216
Applications
WB; IHC; IP; ICC
Application Notes
Cross-reacts with GABA-A-R-Beta2;Does not cross-react with GABA-A-R-Beta1
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GABA(A)R, Beta2/3
Official Name
GABA(A)R, Beta2/3
Full Name
GABA(A)R, Beta2/3
Alternative Names
GABRB2; GABRB3
Product Pictures
IHC
Fig. 1 Adult rat whole brain immunohistochemistry.
IB
Fig. 2 Adult rat brain membrane immunoblot.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
