NeuroMab™ Anti-ADAM17 BBB Shuttle Antibody, Clone 1022C3
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- Inhib; In Vitro
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1A: Comparison of maximal inhibition of Nluc fusion protein AREG shedding by ml022C3 and hzl022C3.
A: Means are significantly different :Unpaired t test (a<0.05) : p=0.0005)
Figure 2 B: Comparing ml022C3 and hzl022C3 for maximal inhibition of Nluc fusion protein shedding AREG (A: means significantly different: unpaired t-test (a<0.05): p=0.0005), TGFa (B: means significantly different : unpaired t-test (a<0.05): p=0.0003) and HB-EGF (C: means significantly different: unpaired t-test (a<0.05): p=0.0069) from stably transfected cell line A431 , the level of untreated cells expressed as a percentage of baseline shedding.
B: Means are significantly different :Unpaired t test (a<0.05) : p=0.0003) and HB-EGF
Figure 3C: Comparison of maximal inhibition of Nluc fusion protein shedding by ml022C3 and hzl022C3 AREG (A: means significantly different: unpaired t-test (a<0.05): p=0.0005), TGFa (B: means significantly different: Unpaired t-test (a<0.05): p=0.0003) and HB-EGF (C: means significantly different: unpaired t-test (a<0.05): p=0.0069) from stably transfected cell line A431, Levels of untreated cells expressed as percentage of baseline shedding.
C: Means are significantly different :Unpaired t test (a<0.05) : p=0.0069) from stably transfected cell line A431 expressed as a percentage of baseline shedding levels of untreated cells.
Figure 4: In vivo activity of 1022C3 on established A431 xenografts.
Figure 5: In vivo activity of 1022C3 on the fragment A431 xenograft model.
Figure 6: Comparison of ml022C3 (murine form) and cl022C3 (chimeric form) on the A431 xenograft model.
Figure 7: In vivo activity of 1022C3 against established CaOV-3 xenografts
Figure 8: In vivo activity of 1022C3 on established OVISE xenografts.
Figure 9: In vivo activity of 1022C3 on established BxPC3 xenografts.
Figure 10A: Comparison of mouse 1022C3 (ml022C3) and its humanized form (hzl022C3) at 1.25 mg/kg on the CaOV3 xenograft model.
Figure 10B: Comparison of mouse 1022C3 (ml022C3) and its humanized form (hzl022C3) when used at 5 mg/kg on a CaOV3 xenograft model.
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