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Creative Biolabs
Product

NeuroMab™ Anti-CD123 BBB Shuttle Antibody, Clone NR12P

[CAT#: NRZP-1022-ZP2415]

Host Species:
Mouse
Species Reactivity:
Human; Cynomolgus Monkey
Applications:
FC; Cyt; ADCC; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Mouse

Clone Number

NR12P

Applications

FC; Cyt; ADCC; In Vitro; In Vivo
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

CD123

Full Name

interleukin-3 receptor

Alternative Names

IL3RA
Product Pictures
FCM

Fig.1 Flow cytomelria analysis of a cell expressing an IL-3RalGM-CSFRa chimeric protein using an anti-IL-3Ra labeled antibody.

The ordinate represents the number of MOLM13 cells, and the abscissa represents the various names of anti-IL-3Ru antibodies.

FCM

Fig.2 Flow cylometry analysis of a cell expressing an IL-3RalGM-CSFRa chimeric protein using an anti-IL-3Ra labeled antibody.

The ordinate represents the number of MOLM13 cells, and the abscissa represents the various names of anti-IL-3Ru antibodies.

Block

Fig.3 Cell growth assay to examine the blocking activity of IL-3 signaling.

The ordinate represents the number of MOLM13 cells, and the abscissa represents the various names of anti-IL-3Ru antibodies.

FuncS

Fig.4 Antitumor effects of various human antibodies in a tumor-bearing model.

The ordinate represents the number of MOLM13 cells, and the abscissa represents the various names of anti-IL-3Ru antibodies.

ADCC

Fig.5 ADCC assay for cell lines expressing IL3Ra using anti-IL-3Ra antibody.

The ordinate represents the number of MOLM13 cells, and the abscissa represents the various names of anti-IL-3Ru antibodies.

FCM

Fig.6 Flow cytometry analysis of cells expressing a Macaca fascicularis IL-3Ru.

The ordinate represents the number of MOLM13 cells, and the abscissa represents the various names of anti-IL-3Ru antibodies.

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For Research Use Only. Not For Clinical Use.
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