NeuroMab™ Anti-CD171 BBB Shuttle Antibody, Clone HzA10A3-2.1

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Isotype

IgG

Clone Number

HzA10A3-2.1

Applications

WB; ELISA; FC; In Vitro; In Vivo

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CD171

Official Name

L1CAM

Full Name

L1 cell adhesion molecule

Alternative Names

L1CAM; CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1; L1 cell adhesion molecule

Product Pictures

ELISA

Figure 1 shows the results of measuring the affinity of A10A3 and cA10-A3 antibodies by the competitive Elisa method.

ELISA

Figure 2 shows the results of measuring the affinity of HzA10A3-1, HzA10A3-2, HzA10A3-2.1, HzA10A3-2.2 antibodies by the competitive Elisa method.

FCM

Figure 3 shows the results of FACS assays using L1CAM-expressing cell lines and non-expressing cell lines to confirm the binding specificity of HzA10A3-2.1 and HzA10A3-2.2 to L1CAM.