NeuroMab™ Anti-CD195 BBB Shuttle Antibody, Clone NR230P
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- Block; Inhib; In Vivo; FC
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 Sustained reduction in viral load.
SCID mice were reconstituted with normal human PBMCs and infected with HIV-1 JR-CSF. When viral steady state was reached, animals were treated ip every three days with a dose of 0.1 mg of a humanized CCR5 antibody (PRO140), and plasma HIV RNA (assayed by Roche Amplicor) was monitored.
Figure 2 Humanized CCR5 antibody (PRO140) efficiently blocks CCR5-mediated HIV-1 cell fusion.
Mouse CCR5 antibody was humanized using complementarity determining region (CDR) grafting and framework replacement. Humanized CCR5 antibodies (PRO 140 #1 and PRO 140 #2) were expressed in Sp2/0 cells, purified by protein A chromatography and tested for their ability to block HIV-1JR-FL env-mediated replication of membrane fusion.
Figure 3 Hu PRO140 blocks HIV-1 but not RANTES signaling.
The ability of PRO140 antibodies to block RANTES-induced calcium mobilization in L1.2-CCR5 cells was tested. This figure shows that a humanized CCR5 antibody (huPRO140) blocks HIV-1 but not RANTES signaling.
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