Product

Human CHO-K1/CCR5/Gα15 Stable Cell Line

[CAT#: NCL20120041CR]

Human chemokine (C-C motif) receptor 5 (CCR5) Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: CHO-K1; GPCR Cell

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Product Overview

Description

C-C chemokine receptor type 5 (CCR5) is a G protein-coupled receptor and a co-receptor for the entry of human immunodeficiency virus-1 (HIV-1) into cells. CCR5 chemokine receptor is involved in leucocytes chemotaxis to sites of inflammation and plays an important role in the macrophages, T cells, and monocytes recruitment. The chemokine ligands that bind to CCR5 are regulated on activation, normal T Cell expressed and secreted (RANTES) and macrophage inflammatory protein 1 alpha (MIP1α).

Cell Types

CHO-K1; GPCR Cell

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 3 μg/ml puromycin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

CCR5

Family

Chemokine receptor

Strain

CCR5/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

CD195

Official Name

CCR5

Full Name

C-C chemokine receptor type 5

Alternative Names

CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5

Gene ID

1234(Human)

Uniprot ID

P51681(Human)

References

1. Watanabe, H., Matsushita, N., Shimizu, Y., Iikuni, S., Nakamoto, Y., Togashi, K., & Ono, M. (2019). Synthesis and characterization of a novel 18 F-labeled 2, 5-diarylnicotinamide derivative targeting orexin 2 receptor. MedChemComm, 10(12), 2126-2130.

Publications