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Creative Biolabs
Product

NeuroMab™ Anti-CX3CR1 BBB Shuttle Antibody, Clone 2A9-1

[CAT#: NRZP-1022-ZP3788]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
Cyt; Neut; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

2A9-1

Applications

Cyt; Neut; In Vitro; In Vivo
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

CX3CR1

Official Name

CX3CR1

Full Name

C-X3-C Motif Chemokine Receptor 1

Alternative Names

GPR13; CMKBRL1
Product Pictures
FuncS

Figure 1A shows the effect of anti-fractalkine (FKN) monoclonal antibody on ConA-induced hepatitis in mice.

FuncS

Figure 1B shows the effect of anti-fractalkine (FKN) monoclonal antibody on ConA-induced hepatitis in mice.

FuncS

Figure 1C shows the effect of anti-fractalkine (FKN) monoclonal antibody on ConA-induced hepatitis in mice.

FuncS

Figure 2A shows the effect of anti-fractalkine (FKN) antibody on cytokine increase 2 hours after ConA injection.

FuncS

Figure 2B shows the effect of anti-fractalkine (FKN) antibody on cytokine increase 2 hours after ConA injection.

FuncS

Figure 3 shows the effect of anti-fractalkine (FKN) antibody on experimental autoimmune encephalomyelitis.

Cyt

Figure 4 shows the cytotoxicity of saporin-labeled anti-CX3CR1 antibody on CX3CR1-expressing cells.

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