NeuroMab™ Anti-IL-1R1 Antibody, Clone 10H7
Functional antibody against Human IL-1R1
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- WB; Inhib; In Vitro
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
Species Reactivity
Clonality
Host Species
Clone Number
Applications
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 is a graph illustrating the inhibitory effect of an anti-IL-1R1 antibody on IL-1R/IL-1β/IL-1 RAcP complex formation.
Figure 2 is a graph showing the ability of anti-IL-1R1 antibodies to block IL-1β binding without significantly interfering with IL-1ra binding compared to an IgG control.
Figure 3 is a graph showing the inhibition of IL-6 production in primary human chondrocytes by anti-IL-IRl antibodies identified herein and designated 15C4, 26F5, and 27F2 compared to IL-lra.
Figure 4 shows the inhibition of IL-6 production in human whole blood by anti-IL-1R1 monoclonal antibodies designated 15C4, 26F5 and 27F2 compared to IL-1ra.
Figure 5 is a graph showing the inhibition of IL-6 production in primary human chondrocytes by IL-1ra and monoclonal antibodies 15C4 and 27F2 compared to the class of monoclonal antibodies represented by 10H7 and 24E12.
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