NeuroMab™ Anti-Netrin 1 BBB Shuttle Antibody, Clone hum03
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- ELISA; Block; Inhib; In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1: In vivo effect of humanized 4C11 antibody (hum03) on the growth of transplantable osteosarcoma in rats.
Rat osteosarcoma tumors were transplanted in paratibial position after denudation of the periosteum (n=7). The rats were treated twice a week by intra-peritoneal injection of 4.4 mg/kg of humanized 4C11 hum03 or an isotypic control with or without doxorubicin (2 mg/kg) or with PBS. The figure displays the tumor fold increase at day 17.
Figure 2: Pepscan analysis of the NET1-binding domain of the anti-Nitidine 1 humanized 4C11 monoclonal antibody (NET1-H-mAb) HUM03. raw
Pepscan data obtained by screening humanized 4C11 mAb against the over-lapping peptide library of 590 linear peptides (x-axis). The signal strength of the interaction is visualized on the y-axis.
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