NeuroMab™ Anti-pTau BBB Shuttle Antibody, Clone hACI-36-3A8-Ab1

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Clone Number

hACI-36-3A8-Ab1

Applications

ELISA; IHC; In Vitro; In Vivo

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

pTau

Full Name

phosphorylated tau

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

ELISA

Figure 1 shows that humanized anti-pTau antibodies hACI-36-2B6-Ab1 and hACI-36 directed against the pTau vaccine peptide (T4.5) do not bind to the non-phosphorylated version of the peptide with (T4.6) homology - 3A8-Ab1.

IHC

Figure 2 shows tau junctions in the brains of 20-month-old Tau transgenic (biGT) mice stained with the humanized anti-pTau antibody hACI-36-2B6-Ab1. Staining showing tau junctions in the cortex (A) and hippocampus (B), and degenerated staining of neural networks visible in the hippocampus (B).