NeuroMab™ Anti-pTau BBB Shuttle Antibody(NRZP-1022-ZP3069)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

Yeast-purified tau

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; WB; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

pTau

Official Name

MAPT

Full Name

phosphorylated tau

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

Figure 1: Analysis of novel mAbs on transgenic mouse and human brain samples.

Western blot analysis of brain extracts from control mice (FVB), knock-out mice and transgenic (Tg) mice expressing a clinical mutant of human tau (Tau-P301L). The age of the mice is indicated between brackets. The arrow on the second blot indicates high molecular weight tau complexes. The antibodies used are ADx215 (YT1.15), ADx210 (YT1.10) and the commercial phosphorylation-specific antibody AT100 (exposure time of 30 min for ADx210 (YT1.10) and AT100, and 30 sec for ADx215 (YT1.15)).

Publications