NeuroMab™ Anti-Siglec-7 BBB Shuttle Antibody, Clone S7-4E3
- Host Species:
- Mouse; Humanized
- Species Reactivity:
- Human; Cynomolgus Monkey; Mouse
- Applications:
- FC; ELISA; Block; In Vitro; In Vivo; Antagonist
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Fig.1 shows FACS analysis of binding of Siglec-7 antibody to human primary dendritic cells compared to isotype control.
Fig.2 anti-Siglec-7 antibodies 4E3 and 10B5 were able to down-regulate cell surface expression of Siglec-7 on primary human dendritic cells.
Fig.3 anti-Siglec-7 antibodies 10B5 and 4E3 inhibit PD-L1 and PD-L2 (PD-1 ligand), B7-H3 (strong T cell checkpoint inhibition on the MDSC surface. Substance), CD200R (inhibitory signaling receptor), and CD163 and CD206 (M2-type markers).
Endpoints after 30h were normalized to isotype control (grey bar) and % aggregated TDP-43 was calculated for ACI-7069- 633B12-AM (dotted grey bar). Mean values ± SD are shown for three independent experiments and statistical differences between isotype control and ACI-7069-633B12-AM (IgG2a variant) were analyzed by Welch's t-tests (***p < 0.001).
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