NeuroMab™ Anti-Synaptotagmin-12 BBB Shuttle Antibody, Clone N277/7

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Synaptotagmin-12 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 168-255 (cytoplasmic C2A domain) of mouse Synaptotagmin-12 (also known as Syt12, Synaptotagmin XII, SytXII, Synaptotagmin-related gene 1 protein, Srg1 and Sytr1, accession number Q920N7)
Rat: 100% identity (88/88 amino acids identical)
Human: 95% identity (84/88 amino acids identical)
>30% identity with Synaptotagmin-6 (and other Synaptotagmins)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N277/7

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Synaptotagmin-6 (or other Synaptotagmins)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Synaptotagmin-12

Official Name

SYT12

Full Name

Synaptotagmin-12

Alternative Names

SRG1; Synaptotagmin 12; synaptotagmin XII; Synaptotagmin-12; SYT11; SYT12; SytXII

Uniprot ID

Q920N7

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Synaptotagmin or untagged Kv2.1 plasmids and probed with N277/7 (left) and N86/8 (right).

Publications