Product
Anti-Synaptotagmin-12 Monoclonal Antibody (CBP3831)
[CAT#: NAB2012335LS]
Anti-Synaptotagmin-12 Monoclonal Antibody [HRP]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Synaptotagmin 12 (Syt12) is regulated by protein kinase A (PKA) and is unique from other synaptotagmins in that it does not bind to Ca2+. Syt12 interaction with Syt1 prevents SNARE complex binding. Expression of Syt12 induces spontaneous neurotransmitter release, providing a mechanism for spontaneous synaptic-vesicle exocytosis that is Ca2+-independent.
Immunogen
This monoclonal antibody was raised against a fusion protein corresponding to amino acids 168-255 (cytoplasmic C2A domain) of mouse Synaptotagmin-12.
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP3831
Applications
WB
Application Notes
WB (5.0-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570
Product Properties
Form
Liquid
Formulation
50% glycerol in aqueous buffered solutions with preservatives.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon receipt, the antibody solution should be stored undiluted at-20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Saheki Y, et al. 2017. Adv Exp Med Biol. 997:83
2. Wang YL, et al. 2017. Cell Mol Life Sci. 74(16):2917
2. Wang YL, et al. 2017. Cell Mol Life Sci. 74(16):2917
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
