NeuroMab™ Anti-TfR BBB Shuttle Antibody, Clone OX26

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Clone Number

OX26

Applications

In Vitro

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Transferrin Receptor

Official Name

TfR

Full Name

Transferrin Receptor

Alternative Names

CD71; TFR1

Product Pictures

FuncS

Figure 1 In vivo plasma pharmacokinetic profiles of anti-TfR antibody affinity variants following systemic administration of 10 mg/kg in rats.

FuncS

Figure 2 Anti-TfR antibody affinity variants (OX26-5, OX26-76, OX26-108, and OX26-174) in rat plasma, brain interstitial fluid, whole brain homogenate, isolated brain capillaries, and postvascular in vivo PK supernatant.

Publications