NeuroMab™ Anti-TRIP8b (exon 1a/5 junction) BBB Shuttle Antibody, Clone N291C/22

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PEX5L BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 1-12 (MYQGHMQLVNEQ, exon 1a (yellow) and exon 5 (green) of constant region) of mouse TRIP8b (also known as TPR-containing Rab8b-interacting protein, Peroxisome biogenesis factor 5-like, Peroxin-5- or PEX5-related/like protein, Pex5Rp, Pex5l, Pex5r, Pex2, Pxr2, accession number Q8C437)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N291C/22

Applications

WB; IHC; ICC

Application Notes

Specific for exon 1a/5 junction (does not react with other TRIP8b isoforms containing exon 1a)

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PEX5L

Official Name

PEX5L

Full Name

TRIP8b (exon 1a/5)

Alternative Names

PEX5R; PXR2; TRIP8b

Uniprot ID

Q8C437

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with carboxyterminally (C) and amino-terminally (N) GFPtagged TRIP8b-1a-5, TRIP8b-1a-4 or untagged Kv2.1 plasmid and probed with N291C/22 (left) and N212/7 (right) TC supe.

Fig. 2 Immunoblot versus crude membranes from adult rat brain (RBM) and WT and TRIP8b KO mouse brains probed with N291C/22 (left) and N52A/42 (right) TC supe.

Publications