Product
NeuroMab™ Anti-TRIP8b (constant) BBB Shuttle Antibody, Clone N212/7
[CAT#: NRZP-0423-ZP434]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PEX5L BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-192 (exon 1a, exon 4 and constant region) of rat TRIP8b (also known as TPR-containing Rab8b-interacting protein, Peroxisome biogenesis factor 5-like, Peroxin5- or PEX5-related/like protein, Pex5Rp, Pex5l, Pex5r, Pex2, Pxr2, accession number Q925N3)
Mouse: 97% identity (147/151 amino acids identical)
Human: 83% identity (180/216 amino acids identical)
Mouse: 97% identity (147/151 amino acids identical)
Human: 83% identity (180/216 amino acids identical)
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N212/7
Applications
WB; IHC; ICC
Application Notes
Cross-reacts with multiple TRIP8b isoforms
Research Areas
Ion channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
PEX5L
Official Name
PEX5L
Full Name
TRIP8b (constant)
Alternative Names
PEX5R; PXR2; TRIP8b
Uniprot ID
Q925N3
Product Pictures
IHC
Fig. 1 Adult rat hippocampus immunohistochemistry.
IB
Fig. 2 Immunoblot versus crude membranes from adult rat brain (RBM) and WT and TRIP8b KO mouse brains probed with N212/7 (left) and N52A/42 (right) TC supe.
IB
Fig. 3 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged TRIP8b-1a-4, TRIP8b-1b-2, TRIP8b-1a-2 or untagged Kv2.1 plasmid and probed with N212/7 (left) or N86/8 (right) TC supe.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
